Kim L Felmingham

TL;DR: Depression without CVD is associated with reducedHRV, which decreases with increasing depression severity, most apparent with nonlinear measures of HRV, highlighting that antidepressant medications might not have HRV-mediated cardioprotective effects and the need to identify individuals at risk among patients in remission.

TL;DR: To determine in physically healthy, unmedicated patients whether heart rate variability is reduced in major depressive disorder relative to controls, and whether HRV reductions are driven by MDD alone, comorbid generalized anxiety disorder (GAD, characterized by anxious anticipation), or comorbrid panic and posttraumatic stress disorders (PD/PTSD, characterize by anxious arousal).

TL;DR: The findings suggest that major life trauma may disrupt the normal pattern of medial prefrontal and amygdala regulation in the amygdala and amygdala search regions of interest.

TL;DR: Excessive fear responses in response to fear-eliciting stimuli may be a key factor in limiting responses to CBT for PTSD and this factor may limit optimal response to therapy.

TL;DR: Functional magnetic resonance imaging results indicate that PTSD participants display increased amygdala and MPFC activity during nonconscious processing of fearful faces, suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing.