K
Kimberly A. Howes
Researcher at University of Utah
Publications - 25
Citations - 1916
Kimberly A. Howes is an academic researcher from University of Utah. The author has contributed to research in topics: Melatonin & Harderian gland. The author has an hindex of 16, co-authored 25 publications receiving 1852 citations. Previous affiliations of Kimberly A. Howes include University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Zhenglin Yang,Nicola J. Camp,Hui Sun,Zongzhong Tong,Daniel Gibbs,D. Joshua Cameron,Haoyu Chen,Yu Zhao,Erik G. Pearson,Xi Li,Jeremy Chien,Andrew T. DeWan,Jennifer Harmon,Paul S. Bernstein,Viji Shridhar,Norman A. Zabriskie,Josephine Hoh,Kimberly A. Howes,Kang Zhang +18 more
TL;DR: A single-nucleotide polymorphism in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%.
Journal ArticleDOI
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
Kimberly A. Howes,Nancy Ransom,David S. Papermaster,Jacques G. H. Lasudry,Daniel M. Albert,Jolene J. Windle,Jolene J. Windle +6 more
TL;DR: The role of p53 in the development of retinoblastoma in mice was addressed and p53 is required for the induction of apoptosis in this model, because mice expressing E7 in a p53 nullizygous background develop retinal tumors instead of undergoing retinal degeneration.
Journal ArticleDOI
Receptor for advanced glycation end products and age-related macular degeneration.
Kimberly A. Howes,Yang Liu,Joshua L. Dunaief,Ann H. Milam,Jeanne M. Frederick,Alexander Marks,Wolfgang Baehr +6 more
TL;DR: Immunolocalization of RAGE in RPE and photoreceptors coincided with AGE deposits and macular disease in aged, early AMD, and GA retinas, contributing to disease progression in the aging human retinas.
Journal Article
Mutant rhodopsin transgene expression on a null background.
Jeanne M. Frederick,Nataliia V. Krasnoperova,Kirstin Hoffmann,Jill Church-Kopish,Klaus Rüther,Kimberly A. Howes,Janis Lem,Wolfgang Baehr +7 more
TL;DR: GHL-rhodopsin dimerizes, localizes to the ER, and fails to transport and support outer segment formation, which indicates a cytotoxic effect of the mutant protein.
Journal ArticleDOI
Structure, alternative splicing, and expression of the human RGS9 gene.
Kang Zhang,Kimberly A. Howes,W. He,J. D. Bronson,Mark J. Pettenati,Ching-Kang Chen,Krzysztof Palczewski,Theodore G. Wensel,Wolfgang Baehr +8 more
TL;DR: The RGS9 gene is a candidate gene for RP17, a form of autosomal retinitis pigmentosa, located on the long arm of chromosome 17 and shows abundant expression in photoreceptors and possibly very low levels in cell types of the inner retina.