K
Kimiko Murakami-Murofushi
Researcher at Ochanomizu University
Publications - 117
Citations - 3975
Kimiko Murakami-Murofushi is an academic researcher from Ochanomizu University. The author has contributed to research in topics: Phosphatidic acid & Physarum polycephalum. The author has an hindex of 30, co-authored 116 publications receiving 3699 citations. Previous affiliations of Kimiko Murakami-Murofushi include University of Tokyo.
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Journal ArticleDOI
Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid
Koji Bandoh,Junken Aoki,Hiroyuki Hosono,Susumu Kobayashi,Tetsuyuki Kobayashi,Kimiko Murakami-Murofushi,Masafumi Tsujimoto,Hiroyuki Arai,Keizo Inoue +8 more
TL;DR: It is demonstrated that EDG7, a new member of the EDG family of G-protein-coupled receptors, is a specific LPA receptor that shows distinct properties from known cloned LPA receptors in ligand specificities, Ca2+ response, modulation of adenylyl cyclase, and MAP kinase activation.
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Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
Munenori Furuse,Yuko Nagase,Hideo Tsubouchi,Kimiko Murakami-Murofushi,Takehiko Shibata,Kunihiro Ohta +5 more
TL;DR: Results indicate that Mre11 has two separable functional domains: the N‐terminal nuclease domain required for DSB repair, and the C-terminal dsDNA‐binding domain essential to its meiotic functions such as chromatin modification and DSB formation.
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Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasis
Daniel L. Baker,Yuko Fujiwara,Kathryn R. Pigg,Ryoko Tsukahara,Susumu Kobayashi,Hiromu Murofushi,Ayako Uchiyama,Kimiko Murakami-Murofushi,Eunjin Koh,Russell W. Bandle,Hoe-Sup Byun,Robert Bittman,Dominic Fan,Mandi M. Murph,Gordon B. Mills,Gabor Tigyi,Gabor Tigyi +16 more
TL;DR: 3-carba analogs of cPA lack significant agonist activity at LPA receptors yet are potent inhibitors of ATX activity, LPA production, and A2058 melanoma cell invasion in vitro and B16F10 melanoma Cell metastasis in vivo.
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A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae.
Utako Kato,Utako Kato,Kazuo Emoto,Charlotta Fredriksson,Hidemitsu Nakamura,Akinori Ohta,Toshihide Kobayashi,Kimiko Murakami-Murofushi,Tetsuyuki Kobayashi,Masato Umeda +9 more
TL;DR: Results suggest that the mutation of ros3affects the PE organization on the plasma membrane, rather than PE synthesis or overall organization of the membrane structures, and indicate that Ros3p is a membrane glycoprotein that plays an important role in the phospholipid translocation across the plasma membranes.
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Early weaning induces anxiety and precocious myelination in the anterior part of the basolateral amygdala of male Balb/c mice.
TL;DR: It is demonstrated that in addition to increasing anxiety, early-weaning manipulations alter the accumulation of galactosylceramide, a specific myelin constituent, and the axonal structure of myelinated fibers in the amygdala of male Balb/c mice.