Kirandeep Kaur

Bio: Kirandeep Kaur is an academic researcher from Guru Nanak Dev University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 9, co-authored 28 publications receiving 1170 citations. Previous affiliations of Kirandeep Kaur include Indian Institute of Technology Bombay & Khalsa College, Amritsar.

Recent advances in antimalarial drug development

Abstract: Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence, and drug resistance, is the most serious and widespread parasitic disease encountered by mankind. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to commonly used drugs such as chloroquine, and the lack of affordable new drugs are the limiting factors in the fight against malaria. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re-examination of the existing antimalarial drugs that may be effective against resistant strains. This review provides an in-depth look at the most significant progress made during the past 10 years in antimalarial drug development.

Morita-Baylis-Hillman and Rauhut-Currier reactions of conjugated nitroalkenes.

Abstract: α-Functionalization of conjugated nitroalkenes and nitrodienes using various electrophiles in the presence of amine catalysts such as imidazole and DMAP and the synthetic applications of the products are reviewed. The electrophiles include formaldehyde, activated non-enolizable carbonyl compounds, activated imines, azodicarboxylates as well as activated alkenes such as nitroalkenes, MVK and acrylate. Reports on synthetic applications of the products, though only appearing in the last three years, highlight the potential of these multi-functional scaffolds to take part in diverse transformations such as Michael addition, cycloaddition and many cascade reactions leading to complex molecules including natural products.

Quinoline as a Privileged Scaffold in Cancer Drug Discovery

Abstract: Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent carbon atoms. Quinoline compounds are widely used as "parental" compounds to synthesize molecules with medical benefits, especially with anti-malarial and anti-microbial activities. Certain quinoline-based compounds also show effective anticancer activity. This broad spectrum of biological and biochemical activities has been further facilitated by the synthetic versatility of quinoline, which allows the generation of a large number of structurally diverse derivatives. This includes numerous analogues derived from substitution of the quinoline ring system, and derivatization of quinoline ring structure. Quinoline and its analogs have recently been examined for their modes of function in the inhibition of tyrosine kinases, proteasome, tubulin polymerization and DNA repair. In this review, we have summarized our knowledge on quinoline compounds with respect to their anticancer activities, mechanisms of action, structure-activity relationship (SAR), and selective and specific activity against various cancer drug targets. In particular, we focus our review on in vitro and in vivo anticancer activities of quinoline and its analogs in the context of cancer drug development and refinement.