Author
Kirill N. Zelenin
Bio: Kirill N. Zelenin is an academic researcher from Military Medical Academy. The author has contributed to research in topics: Tautomer & Ring (chemistry). The author has an hindex of 12, co-authored 45 publications receiving 520 citations.
Topics: Tautomer, Ring (chemistry), Pyridazine, Phthalazine, Pyrazole
Papers
More filters
123 citations
TL;DR: In this paper, ten new hydrazino derivatives were synthesized, and their properties were studied by 1H and 13C NMR spectroscopy, including ring-chain tautomerism, cis-trans isomerism with respect to the substituents in the pyrazole ring, and (E)/(Z) rotamerism with relation to the nitrogen−carbon hydrazide bond with partial double-bond character.
79 citations
TL;DR: In this paper, 32 1,2,3,4-tetrahydroquinazoline derivatives were synthesized by the reaction of 2-aminomethylaniline with aldehydes and ketones and their ring-chain tautomerism was studied by 1H, 13C and 15N NMR spectroscopy.
45 citations
TL;DR: A series of 2-aryl substituted hexahydropyrimidines and perimidines were synthesized from aromatic aldehydes and substituted 1,3-propanediamines or 1,8-naphthalenediamine.
31 citations
29 citations
Cited by
More filters
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.
420 citations
274 citations
256 citations
TL;DR: In this paper, the authors present a survey of the state of the art in Contemp. Org. Synth., 1997, 4, 517676676p and 4, 717676p
Abstract: Covering: January 1997 to December 1998Continuing the coverage in Contemp. Org. Synth., 1997, 4, 517
p
198 citations
TL;DR: In this article, a simple and efficient method from the three-component condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes under solvent-free conditions was presented.
177 citations