Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.

The combinatorial synthesis of bicyclic privileged structures or privileged substructures

The biochemistry and medical significance of the flavonoids.

Recent Developments in Ring Opening Polymerization of Lactones for Biomedical Applications

Polycaprolactone (PCL) is an important polymer due to its mechanical properties, miscibility with a large range of other polymers and biodegradability. Two main pathways to produce polycaprolactone have been described in the literature: the polycondensation of a hydroxycarboxylic acid: 6-hydroxyhexanoic acid, and the ring-opening polymerisation (ROP) of a lactone: e-caprolactone (e-CL). This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems). A surprising variety of catalytic systems have been studied, touching on virtually every section of the periodic table. A detailed list of reaction conditions and catalysts/initiators is given and reaction mechanisms are presented where known. Emphasis is put on the ROP pathway due to its prevalence in the literature and the superior polymer that is obtained. In addition, ineffective systems that have been tried to catalyse the production of PCL are included in the electronic supplementary information for completeness (141 references).

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Synthesis of polycaprolactone: a review

Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

Molecular recognition has been observed in the hydrolysis of peracetates of benzopyranones by lipases from porcine pancreas and Candida cylindracea in organic solvents; the acetoxy group(s) at positions other than peri or ortho to the carbonyl group are hydrolysed preferentially.

Lipase-catalysed selective deacetylation of peracetylated benzopyranones

Conventional therapeutic techniques treat patients by delivering biotherapeutics to the entire body. With targeted delivery, biotherapeutics are transported to the afflicted tissue reducing exposur...

Photopolymerization-based synthesis of iron oxide nanoparticle embedded PNIPAM nanogels for biomedical applications.

Regioselective enzyme-catalyzed deacetylation of benzyl phenyl ketone peracetates in organic solvents

/pdf/the-consistent-force-field-ii-an-optimized-set-of-potential-pozqhivjyc.pdf

The consistent force field. ii: an optimized set of potential energy functions for the alkanes

https://www.rsc.org/suppdata/cc/b7/b712981e/b712981e.pdf

Kirpal S. Bisht

Papers

Lipase-catalysed selective deacetylation of peracetylated benzopyranones

Photopolymerization-based synthesis of iron oxide nanoparticle embedded PNIPAM nanogels for biomedical applications.

Regioselective enzyme-catalyzed deacetylation of benzyl phenyl ketone peracetates in organic solvents

The consistent force field. ii: an optimized set of potential energy functions for the alkanes

Synthesis of resorcin[4]arene cavitands by ring-closing metathesis