Kirpal S. Bisht

Bio: Kirpal S. Bisht is an academic researcher from University of South Florida. The author has contributed to research in topics: Lipase & Candida antarctica. The author has an hindex of 26, co-authored 137 publications receiving 3360 citations. Previous affiliations of Kirpal S. Bisht include University of Massachusetts Lowell & University of Massachusetts Boston.

Compositions, Methods of Use, and Methods of Treatment

Abstract: Embodiments of the present disclosure provide compositions including ketamine analogues, salts, and disalts, pharmaceutical compositions including ketamine analogues, salts, or disalts, methods of treatment of a condition or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Multifold ring closing metathesis reactions in the formation of resorcin[4]arene cavitands

Abstract: The formation of the resorcin[4]arene cavitands using the ring closing metathesis reaction (RCM) in perallylated resorcin[4]arenes was investigated. The formation of resorcinarene cavitands offers unique molecular platforms for host–guest chemistries, sensor development, metal complexation, as well as new polymers and self-assembled systems, and as potential reaction sites, and novel catalytic platforms. In this manuscript we show that cavitand formation by the RCM reaction depends, to a large extent, on the conformation and the substituents on the upper and lower rim of the perallylated resorcin[4]arenes. The perallylation of the octahydroxy compounds disrupted the intramolecular hydrogen bonds causing a dynamic shift in the conformer equilibrium.

Thiocyanation and 2-Amino-1,3-thiazole Formation in Water Using Recoverable and Reusable Glycosylated Resorcin[4]arene Cavitands.

Abstract: A family of three spatially directional resorcin[4]­arene cavitand glycoconjugates (RCGs) have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- and environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that RCGs (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of RCG catalytic systems, that is, RCG1 and RCG3, were also examined upon a simple extraction of the desired products using DCM or ethyl acetate, followed by subjecting the recovered aqueous solution containing the RCG catalysts to the next reaction cycles.

The combinatorial synthesis of bicyclic privileged structures or privileged substructures

Abstract: Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.

Synthesis of polycaprolactone: a review

Abstract: Polycaprolactone (PCL) is an important polymer due to its mechanical properties, miscibility with a large range of other polymers and biodegradability. Two main pathways to produce polycaprolactone have been described in the literature: the polycondensation of a hydroxycarboxylic acid: 6-hydroxyhexanoic acid, and the ring-opening polymerisation (ROP) of a lactone: e-caprolactone (e-CL). This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems). A surprising variety of catalytic systems have been studied, touching on virtually every section of the periodic table. A detailed list of reaction conditions and catalysts/initiators is given and reaction mechanisms are presented where known. Emphasis is put on the ROP pathway due to its prevalence in the literature and the superior polymer that is obtained. In addition, ineffective systems that have been tried to catalyse the production of PCL are included in the electronic supplementary information for completeness (141 references).