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Kirpal S. Bisht

Bio: Kirpal S. Bisht is an academic researcher from University of South Florida. The author has contributed to research in topics: Lipase & Candida antarctica. The author has an hindex of 26, co-authored 137 publications receiving 3360 citations. Previous affiliations of Kirpal S. Bisht include University of Massachusetts Lowell & University of Massachusetts Boston.


Papers
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Journal ArticleDOI
TL;DR: A structure-based virtual screen was applied to identify novel JAK2 inhibitors and G6 demonstrated remarkable potency as well as specificity, which makes it as a potential lead candidate against diseases related to elevated Jak2 tyrosine kinase activity.

49 citations

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TL;DR: The availability of the pendant hydroxyl group is expected to enhance the biodegradability of the polymer and serves in a variety of potential biomedical applications such as polymeric drug delivery systems.

49 citations

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TL;DR: In this paper, the ring-opening polymerization of a monomer containing a free carboxylic acid group was reported for the first time, and six commercially available lipases were screened, and Candida antarctica lipase-B (Novozym-435) and Pseudomonas cepacia lipase were selected to catalyze the copolymerization because of their higher monomer conversions.
Abstract: The ring-opening polymerization of a monomer containing a free carboxylic acid group is reported for the first time. The monomer, 5-methyl-5-carboxyl-1,3-dioxan-2-one (MCC), was copolymerized with trimethylene carbonate (TMC) in an enzymatic ring-opening polymerization conducted in bulk at 80 °C. The low-melting TMC comonomer also solubilized the high-melting MCC monomer, allowing for solvent-free polymerizations. Six commercially available lipases were screened, and Candida antarctica lipase-B (Novozym-435) and Pseudomonas cepacia lipase were selected to catalyze the copolymerization because of their higher monomer conversions. Higher molecular weight polymers (weight-average molecular weight = 7800-9200) were prepared when Novozym-435 was used, with less MCC incorporated into the copolymer than used in the monomer feed. However, Pseudomonas cepacia lipase showed good agreement between the molar feed ratios and the molar composition, but the molecular weights (weight-average molecular weight = 3600-4800) were lower than those obtained when Novozym-435 was used. 13 C NMR spectral data were used for microstructural analysis, which suggested the formation of random, linear, and pendant carboxylic acid groups containing polycarbonates with hydroxyl groups at both chain ends.

46 citations

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TL;DR: The unknown enantiomeric lignan (−)-machilin G and the known lignans (+)-calopiptin, (−)-zuionin A, as well as a new neolignan kadsurin A and known neogenes futoquinol, isodihydrofutoquinoline, ishodihydroidquinol A, isodehydro-futo-quinol B, along with parsley apiole as mentioned in this paper, have been isolated from the leaves and stem of Piper schmidtii

46 citations


Cited by
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Journal ArticleDOI
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
Abstract: Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.

2,620 citations

Journal ArticleDOI
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.

2,424 citations

Journal ArticleDOI
TL;DR: This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field.

1,441 citations

Journal ArticleDOI
TL;DR: This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems).
Abstract: Polycaprolactone (PCL) is an important polymer due to its mechanical properties, miscibility with a large range of other polymers and biodegradability. Two main pathways to produce polycaprolactone have been described in the literature: the polycondensation of a hydroxycarboxylic acid: 6-hydroxyhexanoic acid, and the ring-opening polymerisation (ROP) of a lactone: e-caprolactone (e-CL). This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems). A surprising variety of catalytic systems have been studied, touching on virtually every section of the periodic table. A detailed list of reaction conditions and catalysts/initiators is given and reaction mechanisms are presented where known. Emphasis is put on the ROP pathway due to its prevalence in the literature and the superior polymer that is obtained. In addition, ineffective systems that have been tried to catalyse the production of PCL are included in the electronic supplementary information for completeness (141 references).

1,247 citations

Journal ArticleDOI
Huayu Tian1, Zhaohui Tang1, Xiuli Zhuang1, Xuesi Chen1, Xiabin Jing1 
TL;DR: This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties.

1,088 citations