K
Kirsten E. Lyke
Researcher at University of Maryland, Baltimore
Publications - 100
Citations - 10298
Kirsten E. Lyke is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 35, co-authored 82 publications receiving 7214 citations.
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Journal ArticleDOI
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.
Edward E. Walsh,Robert W. Frenck,Ann R. Falsey,Ann R. Falsey,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,Kathleen M. Neuzil,Mark J. Mulligan,Ruth Bailey,Kena A. Swanson,Ping Li,Kenneth Koury,Warren Kalina,David A. Cooper,Camila R. Fontes-Garfias,Pei Yong Shi,Özlem Türeci,Tompkins Kristin Rachael,Kirsten E. Lyke,Vanessa Raabe,Philip R. Dormitzer,Kathrin U. Jansen,Ugur Sahin,William C. Gruber +25 more
TL;DR: The safety and immunogenicity data from this U.S. phase 1 trial of two vaccine candidates in younger and older adults support the selection of BNT162b2 for advancement to a pivotal phase 2–3 safety and efficacy evaluation.
Journal ArticleDOI
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults.
Mark J. Mulligan,Kirsten E. Lyke,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,Kathleen M. Neuzil,Vanessa Raabe,Ruth Bailey,Kena A. Swanson,Ping Li,Kenneth Koury,Warren Kalina,David A. Cooper,Camila R. Fontes-Garfias,Pei Yong Shi,Özlem Türeci,Tompkins Kristin Rachael,Edward E. Walsh,Edward E. Walsh,Robert W. Frenck,Ann R. Falsey,Ann R. Falsey,Philip R. Dormitzer,William C. Gruber,Ugur Sahin,Kathrin U. Jansen +26 more
TL;DR: In a dose-escalation study of the COVID-19 RNA vaccine BNT162b1 in 45 healthy adults, RBD-binding IgG concentrations and SARS-CoV-2 neutralizing titres in sera increased with dose level and after a second vaccine dose.
Journal ArticleDOI
Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Robert A. Seder,Lee-Jah Chang,Mary E. Enama,Kathryn L Zephir,Uzma N. Sarwar,Ingelise J. Gordon,La Sonji A. Holman,Eric R. James,Peter F. Billingsley,Anusha Gunasekera,Adam D. Richman,Sumana Chakravarty,Anita Manoj,Soundarapandian Velmurugan,Ming Lin Li,Adam Ruben,Tao Li,Abraham G. Eappen,Richard E. Stafford,Sarah H. Plummer,Cynthia S. Hendel,Laura Novik,Pamela Costner,Floreliz Mendoza,Jamie G. Saunders,Martha Nason,Jason H. Richardson,Jittawadee Murphy,Silas A. Davidson,Thomas L. Richie,Martha Sedegah,Awalludin Sutamihardja,Gary A. Fahle,Kirsten E. Lyke,Matthew B. Laurens,Matthew B. Laurens,Mario Roederer,Kavita Tewari,Judith E. Epstein,B. Kim Lee Sim,Julie E. Ledgerwood,Barney S. Graham,Stephen L. Hoffman +42 more
TL;DR: There is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.
Journal ArticleDOI
Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity
J. E. Epstein,Krishnansu S. Tewari,Kirsten E. Lyke,B. K. L. Sim,Peter F. Billingsley,Matthew B. Laurens,Matthew B. Laurens,Anusha Gunasekera,Sumana Chakravarty,Eric R. James,Martha Sedegah,Adam Richman,Soundarapandian Velmurugan,Sharina Reyes,Ming Lin Li,Kathryn Tucker,Adriana Ahumada,Adam Ruben,Tao Li,Richard E. Stafford,Abraham G. Eappen,Cindy Tamminga,Jason W. Bennett,Christian F. Ockenhouse,Jittawadee Murphy,Jack Komisar,N. Thomas,Mark Loyevsky,Ashley J. Birkett,Christopher V. Plowe,Christopher V. Plowe,Christian Loucq,Robert R. Edelman,Thomas L. Richie,Robert A. Seder,Stephen L. Hoffman +35 more
TL;DR: The results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Plasmodium falciparum malaria and suboptimally immunogenic and protective.
Journal ArticleDOI
Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1β), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls
Kirsten E. Lyke,R. Burges,Yacouba Cissoko,Lansana Sangaré,M. Dao,Issa Diarra,Abdoulaye K. Kone,R. Harley,Christopher V. Plowe,Ogobara K. Doumbo,Marcelo B. Sztein +10 more
TL;DR: The complex relationships between inflammatory cytokines and disease in P. falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, are illustrated.