K
Kirsten Littlefield
Researcher at Johns Hopkins University
Publications - 32
Citations - 1553
Kirsten Littlefield is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Antibody & Population. The author has an hindex of 12, co-authored 28 publications receiving 658 citations.
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Journal ArticleDOI
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.
Sabra L. Klein,Andrew Pekosz,Han-Sol Park,Rebecca L. Ursin,Janna R. Shapiro,Sarah E. Benner,Kirsten Littlefield,Swetha Kumar,Harnish Mukesh Naik,Michael J. Betenbaugh,Ruchee Shrestha,Annie A. Wu,Robert M. Hughes,Imani Burgess,Patricio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,David Sullivan,Shmuel Shoham,Andrew D. Redd,Andrew D. Redd,Evan M. Bloch,Arturo Casadevall,Aaron A.R. Tobian +25 more
TL;DR: Male sex, older age, and hospitalization with COVID-19 were associated with increased antibody responses across the serological assays, and IgG titers were greater than either IgM or IgA for S1, full length S, and S-RBD in the overall population.
Journal ArticleDOI
SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.
Hassen Kared,Andrew D. Redd,Evan M. Bloch,Tania S. Bonny,Hermi Sumatoh,Faris Kairi,Daniel Carbajo,Brian Abel,Evan W. Newell,Maria Bettinotti,Sarah E. Benner,Eshan U. Patel,Kirsten Littlefield,Oliver Laeyendecker,Shmuel Shoham,David J. Sullivan,Arturo Casadevall,Andrew Pekosz,Alessandra Nardin,Michael G. Fehlings,Aaron A.R. Tobian,Thomas C. Quinn +21 more
TL;DR: Modelling demonstrated a coordinated and dynamic immune response characterized by a decrease in inflammation, increase in neutralizing antibody titer, and differentiation of a specific CD8+ T cell response.
Journal ArticleDOI
Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers.
Eshan U. Patel,Eshan U. Patel,Evan M. Bloch,William Clarke,Yu Hsiang Hsieh,Denali Boon,Yolanda Eby,Reinaldo E Fernandez,Owen R Baker,Morgan Keruly,Charles S. Kirby,Ethan Klock,Kirsten Littlefield,Jernelle Miller,Haley A Schmidt,Philip Sullivan,Estelle Piwowar-Manning,Ruchee Shrestha,Andrew D. Redd,Andrew D. Redd,Richard E. Rothman,David Sullivan,Shmuel Shoham,Arturo Casadevall,Thomas C. Quinn,Thomas C. Quinn,Andrew Pekosz,Aaron A.R. Tobian,Oliver Laeyendecker,Oliver Laeyendecker +29 more
TL;DR: The diagnostic accuracy of five commercially available EIAs (Abbott, Euroimmun, EDI, ImmunoDiagnostics, and Roche) for detection of IgG or total antibodies to SARS-CoV-2 and neutralizing antibodies (nAbs) was evaluated.
Posted ContentDOI
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.
Sabra L. Klein,Andrew Pekosz,Han-Sol Park,Rebecca L. Ursin,Janna R. Shapiro,Sarah E. Benner,Kirsten Littlefield,Swetha Kumar,Harnish Mukesh Naik,Michael J. Betenbaugh,Ruchee Shrestha,Annie A. Wu,Robert M. Hughes,Imani Burgess,Patricio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,David Sullivan,Shmuel Shoham,Andrew D. Redd,Andrew D. Redd,Evan M. Bloch,Arturo Casadevall,Aaron A.R. Tobian +25 more
TL;DR: There was substantial heterogeneity in the antibody response among potential convalescent plasma donors, but sex, age and hospitalization emerged as factors that can be used to identify individuals with a high likelihood of having strong antiviral antibody levels.
Journal ArticleDOI
SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors.
Sarah E. Benner,Eshan U. Patel,Oliver Laeyendecker,Oliver Laeyendecker,Andrew Pekosz,Kirsten Littlefield,Yolanda Eby,Reinaldo E Fernandez,Jernelle Miller,Charles S Kirby,Morgan Keruly,Ethan Klock,Owen R Baker,Haley A Schmidt,Ruchee Shrestha,Imani Burgess,Tania S. Bonny,William Clarke,Patrizio Caturegli,David J. Sullivan,Shmuel Shoham,Thomas C. Quinn,Thomas C. Quinn,Evan M. Bloch,Arturo Casadevall,Aaron A.R. Tobian,Andrew D. Redd,Andrew D. Redd +27 more
TL;DR: SARS-CoV-2 antibody avidity correlated with duration of infection and higher neutralizing titers, suggesting a potential alternative screening parameter for identifying optimal convalescent plasma donors.