Author
Kit-Lam Chan
Other affiliations: Hoshi University
Bio: Kit-Lam Chan is an academic researcher from Universiti Sains Malaysia. The author has contributed to research in topics: Eurycoma longifolia & Eurycoma. The author has an hindex of 25, co-authored 69 publications receiving 1524 citations. Previous affiliations of Kit-Lam Chan include Hoshi University.
Topics: Eurycoma longifolia, Eurycoma, Ring (chemistry), Quassinoid, Indole test
Papers published on a yearly basis
Papers
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TL;DR: Four quassinoids, 1 and 3 showed higher selectivity indices obtained for the cytotoxicity to antiplasmodial activity ratio than 14,15 beta-dihydroxyklaineanone (2), eurycomanol (5), 6 and 7, and an alkaloid, 9-methoxycanthin-6-one (7), displayed higher antiplaModial activity against Gombak A isolate but were less active against the D10 strain when
113 citations
TL;DR: Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria.
Abstract: Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta, 18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 microM, 0.389-3.498 microM, and 0.504-2.343 microM, respectively, compared with 0.323-0.774 microM for chloroquine.
83 citations
TL;DR: Eurycomanone enhanced testosterone steroidogenesis at the Leydig cells by inhibiting aromatase conversion of testosterone to oestrogen, and at a high concentration may also involve phosphodiesterase inhibition, and may be worthy for further development as a phytomedicine to treat testosterone-deficient male infertility and sterility.
81 citations
TL;DR: A new and simple analytical method using HPLC with fluorescence detection was developed and successfully applied for the quantification of lignans in P. niruri plant samples, finding the highest amount of lIGNans was found in the leaves followed by fruits, branches and stem, whilst the roots have the least amount ofLignans.
71 citations
TL;DR: The present study showed that the antihyperuricemic effect of Phyllanthus niruri methanol extract may be mainly due to its uricosuric action and partly through xanthine oxidase inhibition, whereas the anti hyperuricemia effect of the lignans was attributed to their uricOSURic action.
70 citations
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01 Jan 2014
TL;DR: In this paper, a revision of the previous edition article by Robert Visser, volume 4, pp 551-560, is presented. But this article is based on the previous version of the article.
Abstract: This article is a revision of the previous edition article by Robert Visser, volume 4, pp 551–560, © 2005, Elsevier Inc.
766 citations
TL;DR: In this article, the structural characteristics and separation of lignin in the straws of corn, wheat, rice and flax are discussed, and the first attempt to generalize the information about the structure and processes for the separation of Lignin from hemicellulose and cellulose in lignocellulosic crop residues is made.
692 citations
TL;DR: The present study demonstrated the evidence on synergistic spermatogenic effect of PHF as attributed in ayurveda for the treatment of oligospermia leading to infertility.
Abstract: The therapeutic use of natural herbs is an ancient human civilization act and the numbers of people have reliance on their pharmacological properties and preferred to use the natural herbs. People also use to consume these herbs as supplements to energize, bolster, and eventually enhance sexual ability. Polyherbal formulation (PHF) is one of these herbal amalgams that can be used to treat sexual dysfunction including erectile dysfunction, impotence, ejaculation dysfunction, and hypogonadism. The pilot study was aimed at evaluating the capacity of PHF in enhancing the spermatogenic potential of oligospermic patients. Thirty-six male patients with oligospermia were enrolled and randomized either to treatment (n = 23) with PHF (750 mg/d in three doses for 90 days) or to placebo (n = 13) in the same protocol. The preintervention semen analysis was compared with posttreatment semen analysis. Based on the postintervention semen analysis, patients were advised to undergo either in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to assess their fertility status. After polyherbal treatment, there was a 256% increase in sperm concentration (9.59 ± 4.37 × 106/mL to 25.61 ± 8.6 × 106/mL; P ≤0.001), 154% increase in semen volume (1.7 ± 0.14 mL to 4.32 ± 0.38 mL; P ≤0.001), and 215% increase in sperm motility (15.43 ± 2.40% to 48.65 ± 5.10%; P ≤ 0.001) on day 90 from baseline. Furthermore, a significant improvement and regulation were also observed in serum hormone levels with PHF treatment as compared to the placebo group. The present study demonstrated the evidence on synergistic spermatogenic effect of PHF as attributed in ayurveda for the treatment of oligospermia leading to infertility.
648 citations