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Klaus Okkenhaug
Researcher at University of Cambridge
Publications - 146
Citations - 19088
Klaus Okkenhaug is an academic researcher from University of Cambridge. The author has contributed to research in topics: T cell & P110δ. The author has an hindex of 62, co-authored 139 publications receiving 16993 citations. Previous affiliations of Klaus Okkenhaug include Ludwig Institute for Cancer Research & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Requirement of bic/microRNA-155 for normal immune function.
Antony Rodriguez,Elena Vigorito,Simon Clare,Madhuri Warren,Madhuri Warren,Philippe Couttet,Dalya R. Soond,Stijn van Dongen,Russell J. Grocock,Partha Pratim Das,Eric A. Miska,David Vetrie,Klaus Okkenhaug,Anton J. Enright,Gordon Dougan,Martin R Turner,Allan Bradley +16 more
TL;DR: It is shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling, and suggests that bic-micro RNA-155 plays a key role in the homeostasis and function of the immune system.
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Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer
TL;DR: This review uses transgenic and knockout mouse studies where either PI3K or its signaling components are deregulated as a framework to build a profile of PI3k function within both the cell and the organism and focuses, in particular, on the role ofPI3K in cell regulation, immunity, and development.
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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman,Jennifer M. A. Tullet,Daniela Wieser,Elaine E. Irvine,Steven J. Lingard,Agharul I. Choudhury,Marc Claret,Hind Al-Qassab,Danielle Carmignac,Faruk Ramadani,Angela Woods,Iain C. A. F. Robinson,Eugene Schuster,Rachel L. Batterham,Sara C. Kozma,George Thomas,David Carling,Klaus Okkenhaug,Janet M. Thornton,Linda Partridge,David Gems,Dominic J. Withers,Dominic J. Withers +22 more
TL;DR: It is shown in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity.
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Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
Klaus Okkenhaug,Antonio Bilancio,Géraldine Farjot,Helen Priddle,Sara Sancho,Emma Peskett,Wayne Pearce,Stephen Meek,Ashreena Salpekar,Michael D. Waterfield,Michael D. Waterfield,Andrew J.H. Smith,Bart Vanhaesebroeck,Bart Vanhaesebroeck +13 more
TL;DR: Results reveal a selective role for p110δ in immunity and suggest second messenger signals downstream of tyrosine kinases influence cell metabolism, growth, proliferation, differentiation, motility, and survival.
Journal ArticleDOI
PI3K in lymphocyte development, differentiation and activation
TL;DR: New insights into the role of PI3Ks in lymphocyte biology have been derived from gene-targeting studies, which have identified thePI3K subunits that are involved in B-cell and T-cell signalling.