K
Kleshchevnikov
Researcher at Wellcome Trust Sanger Institute
Publications - 3
Citations - 45
Kleshchevnikov is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cas9 & Genomics. The author has an hindex of 2, co-authored 3 publications receiving 19 citations.
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Mutations generated by repair of Cas9-induced double strand breaks are predictable from surrounding sequence
Felicity Allen,Luca Crepaldi,Clara Alsinet,Alex Strong,Kleshchevnikov,Angeli Pd,Palenikova P,Michael Kosicki,Andrew R. Bassett,Heather P. Harding,Yaron Galanty,Muñoz-Martínez F,Emmanouil Metzakopian,Stephen P. Jackson,Leopold Parts +14 more
TL;DR: A systematic study of the sequence determinants of the produced mutations at individual loci of CRISPR/Cas9 editing outcomes is presented, which allows better design of editing experiments, and may lead to future therapeutic applications.
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Spatial genomics maps the structure, character and evolution of cancer clones
Lomakin A,Lomakin A,Svedlund J,Svedlund J,Carina Strell,Carina Strell,Milana Gataric,Artem Shmatko,Artem Shmatko,Artem Shmatko,Jun Sung Park,Jun Sung Park,Young Seok Ju,Stefan C. Dentro,Stefan C. Dentro,Kleshchevnikov,Vaskivskyi,Tong Li,Omer Ali Bayraktar,Luiza Moore,S. Pinder,Andrea L. Richardson,Peter J. Campbell,Moritz Gerstung,Mats Nilsson,Lucy R. Yates +25 more
TL;DR: In this paper, the authors developed base specific in situ sequencing (BaSISS) to detect transcripts harboring clone-defining mutations, converted into quantitative clone maps and characterised through multi-layered data integration.
Posted ContentDOI
Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs
TL;DR: In this paper, the authors aim to discover human linear motifs convergently evolved also in disordered regions of viral proteins, under the hypothesis that these will result in enrichment in functional motif instances.