K
Knut M. Wittkowski
Researcher at Rockefeller University
Publications - 80
Citations - 5596
Knut M. Wittkowski is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antigen & Psoriasis. The author has an hindex of 29, co-authored 77 publications receiving 5350 citations. Previous affiliations of Knut M. Wittkowski include Baylor University Medical Center & University of Tübingen.
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Journal Article
Immune and Clinical Responses in Patients with Metastatic Melanoma to CD34+ Progenitor-derived Dendritic Cell Vaccine
Jacques Banchereau,A. Karolina Palucka,Madhav V. Dhodapkar,Susan Burkeholder,Nicolas Taquet,Alexandre Rolland,Sybil Taquet,Sebastien Coquery,Knut M. Wittkowski,Nina Bhardwaj,L. Pineiro,Ralph M. Steinman,Joseph W. Fay +12 more
TL;DR: The overall immunity to MelAgs after DC vaccination is associated with clinical outcome (P = 0.015), and of 17 patients with evaluable disease, 6 of 7 patients with immunity to two or less Mel Ags had progressive disease 10 weeks after study entry, in contrast to tumor progression in only 1 of 10 patients with Immunity to >2 MelAgS.
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A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
Damien Chaussabel,Charles T. Quinn,Jing Shen,Pinakeen Patel,Casey Glaser,Nicole Baldwin,Dorothee Stichweh,Derek Blankenship,Lei Li,Indira Munagala,Lynda Bennett,Florence Allantaz,Asuncion Mejias,Monica I. Ardura,Ellen Kaizer,Laurence Monnet,Windy Allman,Henry B. Randall,Diane Johnson,Aimee Lanier,Marilynn Punaro,Knut M. Wittkowski,Perrin C. White,Joseph W. Fay,Goran B. Klintmalm,Octavio Ramilo,A. Karolina Palucka,Jacques Banchereau,Virginia Pascual +28 more
TL;DR: This work designed a strategy for microarray analysis that is based on the identification of transcriptional modules formed by genes coordinately expressed in multiple disease data sets that provide a stable framework for the visualization and functional interpretation of microarray data.
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Gene expression patterns in blood leukocytes discriminate patients with acute infections
Octavio Ramilo,Octavio Ramilo,Windy Allman,Wendy K. Chung,Wendy K. Chung,Asuncion Mejias,Asuncion Mejias,Monica Ardura,Monica Ardura,Casey Glaser,Knut M. Wittkowski,Bernard Piqueras,Jacques Banchereau,A. Karolina Palucka,Damien Chaussabel +14 more
TL;DR: In this paper, gene expression profiles were obtained for 131 peripheral blood samples from pediatric patients with acute infections caused by influenza A virus, Gram-negative (Escherichia coli) or Gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) bacteria.
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Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation
Hermann Einsele,Gerhard Ehninger,Holger Hebart,Knut M. Wittkowski,Schuler U,Gerhard Jahn,P. Mackes,M. Herter,Thomas Klingebiel,Jürgen Löffler,Silvia Wagner,Claudia A. Müller +11 more
TL;DR: Preemptive therapy based on more sensitive detection methods such as the PCR assay reduces the incidence of CMV disease and CMV-related mortality and allows reduction of the duration and side effects of antiviral therapy.
Journal ArticleDOI
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
Michelle A. Lowes,Francesca Chamian,Maria Veronica Abello,Judilyn Fuentes-Duculan,Shao Lee Lin,Rachel Nussbaum,Inna Novitskaya,Henrietta Carbonaro,Irma Cardinale,Toyoko Kikuchi,Patricia Gilleaudeau,Mary Sullivan-Whalen,Knut M. Wittkowski,Kim A. Papp,Marvin Garovoy,Wolfgang Dummer,Ralph M. Steinman,James G. Krueger +17 more
TL;DR: A type of DC, which resembles murine "Tip-DCs" that can accumulate during infection, has proinflammatory effects in psoriasis through nitric oxide and TNF-alpha production, and can be an important target for suppressive therapies.