Koen Augustyns

TL;DR: The steady-state catalytic parameters for a relevant selection of chemokines previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV-catalyzed truncation are determined and reveal a striking selectivity for stromal cell-derived factor-1α (CXCL12) and macrophage-derived chemokine (CCL22).

TL;DR: NH2-terminal truncation of MDC by CD26/DPP IV has profound biological consequences and may be an important regulatory mechanism during the migration of Th2 lymphocytes and dendritic cells to germinal centers and to sites of inflammation.

TL;DR: In this paper, the authors explored the structure-activity relationship around the core scaffold of the N-4-quinolinoyl-gly-(2S)-cyanoPro scaffold and reported extensively optimized compounds that display low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (DPPs) DPPIV, DPP9, and prolyl oligopeptidase (PREP).

TL;DR: Several caffeic acid esters isolated from propolis exhibit interesting antioxidant properties, but their in vivo use is compromised by hydrolysis of the ester bond in the gastrointestinal tract, so their in vitro antioxidant profile was determined.

TL;DR: These results not only report on new and very potent RIPK1 inhibitors but also highlight the risk of misinterpretation when using these two PERK inhibitors in the context of ER stress, cell death and inflammation.