K
Kohei Kometani
Researcher at Kyoto University
Publications - 39
Citations - 3419
Kohei Kometani is an academic researcher from Kyoto University. The author has contributed to research in topics: Cellular differentiation & Bone marrow. The author has an hindex of 24, co-authored 38 publications receiving 2672 citations. Previous affiliations of Kohei Kometani include Yale University & Max Planck Society.
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Journal ArticleDOI
Memory B cells.
TL;DR: This Review discusses the underlying mechanisms that are required for rapid and effective recall antibody responses in memory B cells, focusing on the contributions of other types of cells, such as memory T follicular helper cells.
Journal ArticleDOI
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion
Takanori Kitamura,Kohei Kometani,Hiroki Hashida,Akihiro Matsunaga,Hiroyuki Miyoshi,Hisahiro Hosogi,Masahiro Aoki,Masanobu Oshima,Masanobu Oshima,Masakazu Hattori,Arimichi Takabayashi,Nagahiro Minato,Makoto Mark Taketo +12 more
TL;DR: It is shown that a new type of immature myeloid cell (iMC) is recruited from the bone marrow to the tumor invasion front and accumulation of iMCs that promote tumor invasion in cis-Apc/Smad4 mice.
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Regulated selection of germinal-center cells into the memory B cell compartment
Ryo Shinnakasu,Takeshi Inoue,Kohei Kometani,Saya Moriyama,Yu Adachi,Manabu Nakayama,Yoshimasa Takahashi,Hidehiro Fukuyama,Takaharu Okada,Tomohiro Kurosaki +9 more
TL;DR: An instructive model is proposed in which weak help from T cells maintains relatively high expression of Bach2, which predisposes GC cells to enter the memory pool.
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KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Dietmar Herndler-Brandstetter,Harumichi Ishigame,Ryo Shinnakasu,Valerie Plajer,Carmen Stecher,Jun Zhao,Melanie Lietzenmayer,Lina Kroehling,Akiko Takumi,Kohei Kometani,Takeshi Inoue,Yuval Kluger,Susan M. Kaech,Tomohiro Kurosaki,Takaharu Okada,Richard A. Flavell +15 more
TL;DR: It is demonstrated that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long‐term protective immunity and drives functional diversity within memory T cell lineages and promotes enhanced anti‐influenza and anti‐tumor immunity.
Journal ArticleDOI
T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate
Wataru Ise,Kentaro Fujii,Katsuyuki Shiroguchi,Ayako Ito,Kohei Kometani,Kiyoshi Takeda,Eiryo Kawakami,Kazuo Yamashita,Kazuhiro Suzuki,Takaharu Okada,Tomohiro Kurosaki +10 more
TL;DR: The data support a model whereby commitment to the plasma cell begins in the GC and suggest that stability of Tfh‐GC B cell contacts is key for plasma cell‐prone GC cell formation.