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Koji Amano

Bio: Koji Amano is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Lipodystrophy. The author has an hindex of 1, co-authored 2 publications receiving 1 citations.
Topics: Lipodystrophy

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01 Jan 1999
Abstract: Highly active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome of peripheral fat wasting and central adiposity. HIV-1 protease inhibitors are generally believed to be the causal agents, although the syndrome has also been observed with protease-inhibitor-sparing regimens. Here, we postulate that the mitochondrial toxicity of the nucleoside-analogue reverse-transcriptase inhibitors plays an essential part in the development of this lipodystrophy, similar to the role of mitochondrial defects in the development of multiple symmetrical lipomatosis.

28 citations