K
Koji Eto
Researcher at Kyoto University
Publications - 203
Citations - 15840
Koji Eto is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 47, co-authored 191 publications receiving 14567 citations. Previous affiliations of Koji Eto include Scripps Research Institute & Chiba University.
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Journal ArticleDOI
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
Journal ArticleDOI
CD8 + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Satoshi Nishimura,Ichiro Manabe,Mika Nagasaki,Koji Eto,Hiroshi Yamashita,Mitsuru Ohsugi,Makoto Otsu,Hara Kazuo,Kohjiro Ueki,Seiryo Sugiura,Kotaro Yoshimura,Takashi Kadowaki,Ryozo Nagai +12 more
TL;DR: The findings suggest that obese adipose tissue activates CD8+ T cells, which, in turn, promote the recruitment and activation of macrophages in this tissue, which supports the notion that CD8- T cells have an essential role in the initiation and propagation of adipose inflammation.
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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Seiji Tadokoro,Sanford J. Shattil,Koji Eto,Vera Tai,Robert C. Liddington,José M. de Pereda,Mark H. Ginsberg,David A. Calderwood +7 more
TL;DR: It is reported that specific binding of the cytoskeletal protein talin to integrin β subunit cytoplasmic tails leads to the conformational rearrangements of integrin extracellular domains that increase their affinity.
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Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton
Achim Obergfell,Koji Eto,Attila Mócsai,Charito S. Buensuceso,Sheri L. Moores,Joan S. Brugge,Clifford A. Lowell,Sanford J. Shattil +7 more
TL;DR: It is established that platelet spreading on fibrinogen requires sequential activation of Src and Syk in proximity to αIIbβ3, thus providing a paradigm for initiation of integrin signaling to the actin cytoskeleton.
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Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Toshinobu Nishimura,Shin Kaneko,Ai Kawana-Tachikawa,Yoko Tajima,Haruo Goto,Dayong Zhu,Kaori Nakayama-Hosoya,Shoichi Iriguchi,Yasushi Uemura,Takafumi Shimizu,Naoya Takayama,Daisuke Yamada,Ken Nishimura,Manami Ohtaka,Nobukazu Watanabe,Satoshi Takahashi,Aikichi Iwamoto,Haruhiko Koseki,Mahito Nakanishi,Koji Eto,Hiromitsu Nakauchi +20 more
TL;DR: This work reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency and found that this method can be effective for generating specific T-cells for other pathology-associated antigens.