K
Konrad Hochedlinger
Researcher at Harvard University
Publications - 172
Citations - 38007
Konrad Hochedlinger is an academic researcher from Harvard University. The author has contributed to research in topics: Reprogramming & Induced pluripotent stem cell. The author has an hindex of 77, co-authored 166 publications receiving 35354 citations. Previous affiliations of Konrad Hochedlinger include University of Vienna & Free University of Berlin.
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Journal ArticleDOI
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Marius Wernig,Alexander Meissner,Ruth K. Foreman,Tobias Brambrink,Manching Ku,Konrad Hochedlinger,Konrad Hochedlinger,Bradley E. Bernstein,Bradley E. Bernstein,Rudolf Jaenisch +9 more
TL;DR: The results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells.
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Disease-Specific Induced Pluripotent Stem Cells
In-Hyun Park,Natasha Arora,Hongguang Huo,Nimet Maherali,Tim Ahfeldt,Tim Ahfeldt,Akiko Shimamura,M. William Lensch,M. William Lensch,Chad A. Cowan,Konrad Hochedlinger,George Q. Daley +11 more
TL;DR: The generation of induced pluripotent stem cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance are described, offering an unprecedented opportunity to recapitulate both normal and pathologic human tissue formation in vitro, thereby enabling disease investigation and drug development.
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Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution
Nimet Maherali,Rupa Sridharan,Wei Xie,Jochen Utikal,Sarah Eminli,Katrin Arnold,Matthias Stadtfeld,Robin Yachechko,Jason Tchieu,Rudolf Jaenisch,Kathrin Plath,Konrad Hochedlinger +11 more
TL;DR: Genome-wide analysis of two key histone modifications indicated that iPS cells are highly similar to ES cells, and data show that transcription factor-induced reprogramming leads to the global reversion of the somatic epigenome into an ES-like state.
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Induced pluripotent stem cells generated without viral integration
Matthias Stadtfeld,Masaki Nagaya,Masaki Nagaya,Jochen Utikal,Gordon C. Weir,Gordon C. Weir,Konrad Hochedlinger +6 more
TL;DR: This work generated mouse induced pluripotent stem cells from fibroblasts and liver cells by using nonintegrating adenoviruses transiently expressing Oct4, Sox2, Klf4, and c-Myc, providing strong evidence that insertional mutagenesis is not required for in vitro reprogramming.
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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Jose M. Polo,Susanna Liu,Maria E. Figueroa,Warakorn Kulalert,Sarah Eminli,Kah Yong Tan,Effie Apostolou,Matthias Stadtfeld,Yushan Li,Toshihiro Shioda,Sridaran Natesan,Amy J. Wagers,Ari Melnick,Todd Evans,Konrad Hochedlinger +14 more
TL;DR: It is shown that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns, and it is demonstrated that cellular origin influences the in vitro differentiation potentials of iPSC into embryoid bodies and different hematopsic cell types.