K
Konrad L. Streetz
Researcher at RWTH Aachen University
Publications - 94
Citations - 5921
Konrad L. Streetz is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Liver injury & Hepatocyte. The author has an hindex of 32, co-authored 90 publications receiving 5502 citations. Previous affiliations of Konrad L. Streetz include Stanford University & Hochschule Hannover.
Papers
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Journal ArticleDOI
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.
Dirk Grimm,Konrad L. Streetz,Konrad L. Streetz,Catherine L. Jopling,Theresa A. Storm,Kusum Pandey,Corrine R. Davis,Patricia L. Marion,Felix H. Salazar,Mark A. Kay +9 more
TL;DR: The risk of oversaturating endogenous small RNA pathways can be minimized by optimizing shRNA dose and sequence, as exemplified here by the report of persistent and therapeutic RNAi against human hepatitis B virus in vivo.
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The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release
Cynthia A. Bradham,Ting Qian,Konrad L. Streetz,Christian Trautwein,David A. Brenner,John J. Lemasters +5 more
TL;DR: The MPT is an essential component in the signaling pathway for TNFα-induced apoptosis in hepatocytes which is required for both cytochrome c release and cell death and functions downstream of FADD and crmA but upstream of caspase 3.
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Experimental liver fibrosis research: update on animal models, legal issues and translational aspects
Christian Liedtke,Tom Luedde,Tilman Sauerbruch,D. Scholten,Konrad L. Streetz,Frank Tacke,Rene Tolba,Christian Trautwein,Jonel Trebicka,Ralf Weiskirchen +9 more
TL;DR: This review gives an update on current animal models, techniques and underlying pathomechanisms with the aim of fostering a critical discussion of the limitations and potential of up-to-date animal experimentation.
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Interleukin 6 and liver regeneration
TL;DR: The multifunctional cytokine interleukin 6 (IL-6) was cloned in 1986 and since then, understanding of its role in the regulatory functions in the immune system has grown steadily.
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Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
Marie-Luise Berres,Rory R. Koenen,Anna Rueland,Mirko Moreno Zaldivar,D Heinrichs,H Sahin,P. Schmitz,Konrad L. Streetz,Thomas Berg,Nikolaus Gassler,Ralf Weiskirchen,Amanda E. I. Proudfoot,Christian Weber,Christian Trautwein,Hermann E. Wasmuth +14 more
TL;DR: The results define a successful therapeutic approach to reduce experimental liver fibrosis by antagonizing Ccl5 receptors and show that treatment with the CCL5 receptor antagonist Met-CCL5 inhibited cultured stellate cell migration, proliferation, and chemokine and collagen secretion.