K
Korrapati V. Sathyasaikumar
Researcher at University of Maryland, Baltimore
Publications - 25
Citations - 1908
Korrapati V. Sathyasaikumar is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Kynurenine & Kynurenic acid. The author has an hindex of 15, co-authored 22 publications receiving 1664 citations. Previous affiliations of Korrapati V. Sathyasaikumar include University of Hyderabad.
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Journal ArticleDOI
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Daniel Zwilling,Shao-Yi Huang,Korrapati V. Sathyasaikumar,Francesca M. Notarangelo,Paolo Guidetti,Hui-Qiu Wu,Jongmin Lee,Jennifer Truong,Yaisa Andrews-Zwilling,Eric Hsieh,Jamie Y. Louie,Tiffany Wu,Kimberly Scearce-Levie,Christina Patrick,Anthony Adame,Flaviano Giorgini,Saliha Moussaoui,Grit Laue,Arash Rassoulpour,Gunnar Flik,Yadong Huang,Joseph M. Muchowski,Eliezer Masliah,Robert Schwarcz,Paul J. Muchowski +24 more
TL;DR: Chronic oral administration of JM6 inhibits KMO in the blood, increasing kynurenic acid levels and reducing extracellular glutamate in the brain, and it extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease.
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The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease
Susanna Campesan,Edward W. Green,Carlo Breda,Korrapati V. Sathyasaikumar,Paul J. Muchowski,Robert Schwarcz,Charalambos P. Kyriacou,Flaviano Giorgini +7 more
TL;DR: This study provides the first genetic evidence that inhibition of KMO and TDO activity protects against neurodegenerative disease in an animal model, indicating that strategies targeted at two key points within the KP may have therapeutic relevance in HD, and possibly other neuro degenerative disorders.
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Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia
Korrapati V. Sathyasaikumar,Erin K. Stachowski,Ikwunga Wonodi,Rosalinda C. Roberts,Rosalinda C. Roberts,Arash Rassoulpour,Robert P. McMahon,Robert Schwarcz +7 more
TL;DR: The present results further support the hypothesis that the normalization of cortical KP metabolism may constitute an effective new treatment strategy in SZ.
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Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease
TL;DR: Data supporting the idea that metabolites of the kynurenine pathway (KP) of tryptophan degradation provide a critical link between mutant htt and the pathophysiology of HD are reviewed, and pharmacological normalization of the imbalance in brain KP metabolism may provide clinical benefits.
Journal ArticleDOI
Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes
Ikwunga Wonodi,O. Colin Stine,Korrapati V. Sathyasaikumar,Rosalinda C. Roberts,Braxton D. Mitchell,L. Elliot Hong,Yasushi Kajii,Gunvant K. Thaker,Robert Schwarcz +8 more
TL;DR: The results provide converging lines of evidence implicating reduced KMO activity in the etiopathophysiology of schizophrenia and related neurocognitive deficits.