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Kosuke Nakashima

Bio: Kosuke Nakashima is an academic researcher from Tokyo University of Pharmacy and Life Sciences. The author has contributed to research in topics: Conjugate & Organocatalysis. The author has an hindex of 12, co-authored 44 publications receiving 413 citations. Previous affiliations of Kosuke Nakashima include University of Tokyo & Gifu Pharmaceutical University.


Papers
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Journal ArticleDOI
TL;DR: Oxidation of alcohols in the presence of a catalytic amount of fluorous IBX and Oxone as a co-oxidant resulted in the corresponding carbonyl compounds in good to high yields.

45 citations

Journal ArticleDOI
TL;DR: In this article, primary amine thiourea organocatalyst 8 was used to promote the addition of bulky α,α-disubstituted aldehydes, such as isobutyraldehyde with maleimides to afford the corresponding adducts in high to excellent yields and with up to 91% ee.
Abstract: Primary amine thiourea organocatalyst 8 was used to promote Michael additions of bulky α,α-disubstituted aldehydes, such as isobutyraldehyde with maleimides to afford the corresponding adducts in high to excellent yields and with up to 91% ee.

43 citations

Journal ArticleDOI
TL;DR: The pyrrolidine-diaminomethylenemalononitrile organocatalyst 7 promotes the asymmetric conjugate addition of a carbonyl compound to a nitroalkene to afford the corresponding adduct in high yield with up to 99% ee, under solvent-free conditions as mentioned in this paper.

31 citations

Journal ArticleDOI
TL;DR: Diaminomethylenemalononitrile organocatalyst 1 efficiently promotes the asymmetric conjugate addition of malonates to α,β-unsaturated ketones to afford the corresponding addition products in high to excellent yields with up to 98% ee as mentioned in this paper.

29 citations


Cited by
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Journal ArticleDOI
TL;DR: One of the goals of this Review is to attract the attention of the scientific community as to the benefits of using hypervalent iodine compounds as an environmentally sustainable alternative to heavy metals.
Abstract: The preparation, structure, and chemistry of hypervalent iodine compounds are reviewed with emphasis on their synthetic application. Compounds of iodine possess reactivity similar to that of transition metals, but have the advantage of environmental sustainability and efficient utilization of natural resources. These compounds are widely used in organic synthesis as selective oxidants and environmentally friendly reagents. Synthetic uses of hypervalent iodine reagents in halogenation reactions, various oxidations, rearrangements, aminations, C–C bond-forming reactions, and transition metal-catalyzed reactions are summarized and discussed. Recent discovery of hypervalent catalytic systems and recyclable reagents, and the development of new enantioselective reactions using chiral hypervalent iodine compounds represent a particularly important achievement in the field of hypervalent iodine chemistry. One of the goals of this Review is to attract the attention of the scientific community as to the benefits of...

1,228 citations

Journal ArticleDOI
TL;DR: Recent remarkable progress with primary amine-thioureas can successfully catalyze a diverse variety of highly enantioselective transformations providing a wide range of versatile organic compounds.
Abstract: Research disclosed since the demonstration of the first examples of primary amine-thiourea organocatalysis in 2006 has shown that primary amine-based thioureas can successfully catalyze a diverse variety of highly enantioselective transformations providing a wide range of versatile organic compounds. Recent remarkable progress with these chiral catalysts is summarized in this review.

265 citations

Journal ArticleDOI
TL;DR: In this Focus Review, recent developments of hypervalent iodine-catalyzed reactions are described including some asymmetric variants.
Abstract: Hypervalent iodine chemistry is now a well-established area of organic chemistry. Novel hypervalent iodine reagents have been introduced in many different transformations owing to their mild reaction conditions and environmentally friendly nature. Recently, these reagents have received particular attention because of their applications in catalysis. Numerous hypervalent iodine-catalyzed oxidative functionalizations such as oxidations of various alcohols and phenols, α-functionalizations of carbonyl compounds, cyclizations, and rearrangements have been developed successfully. In these catalytic reactions stoichiometric oxidants such as mCPBA or oxone play a crucial role to generate the iodine(III) or iodine(V) species in situ. In this Focus Review, recent developments of hypervalent iodine-catalyzed reactions are described including some asymmetric variants. Catalytic reactions using recyclable hypervalent iodine catalysts are also covered.

258 citations

Journal ArticleDOI
TL;DR: This feature article reviews some of the remarkable advancements that have made it possible to develop even more sustainable asymmetric organocatalyzed methodologies.

216 citations