K
Kotb Abdelmohsen
Researcher at National Institutes of Health
Publications - 163
Citations - 21231
Kotb Abdelmohsen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA-binding protein & Gene silencing. The author has an hindex of 63, co-authored 145 publications receiving 17825 citations. Previous affiliations of Kotb Abdelmohsen include Catalan Institution for Research and Advanced Studies & University of Maryland, Baltimore.
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Journal ArticleDOI
Transcriptome signature of cellular senescence.
Gabriel Casella,Rachel Munk,Kyoung Mi Kim,Yulan Piao,Supriyo De,Kotb Abdelmohsen,Myriam Gorospe +6 more
TL;DR: It is proposed that these shared transcriptome profiles will enable the identification of senescent cells in vivo, the investigation of their roles in aging and malignancy and the development of strategies to target senescence cells therapeutically.
Journal ArticleDOI
HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP
Ji Heon Noh,Kyoung Mi Kim,Kotb Abdelmohsen,Je-Hyun Yoon,Amaresh C. Panda,Rachel Munk,Jiyoung Kim,Jessica Curtis,Christopher A. Moad,Christina M. Wohler,Fred E. Indig,Wilson B. M. de Paula,Dawood B. Dudekula,Supriyo De,Yulan Piao,Xiaoling Yang,Jennifer L. Martindale,Rafael de Cabo,Myriam Gorospe +18 more
TL;DR: These findings indicate that RBPs HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria.
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Identification of senescent cell surface targetable protein DPP4.
Kyoung Mi Kim,Ji Heon Noh,Monica Bodogai,Jennifer L. Martindale,Xiaoling Yang,Fred E. Indig,Sandip K. Basu,Kei Ohnuma,Chikao Morimoto,Peter F. Johnson,Arya Biragyn,Kotb Abdelmohsen,Myriam Gorospe +12 more
TL;DR: Mass spectrometry analysis revealed that DPP4 was selectively expressed on the surface of senescent, but not proliferating, human diploid fibroblasts, which allowed flow cytometry-mediated isolation of Senescent cells using anti-DPP4 antibodies.
Journal ArticleDOI
Ubiquitin‐mediated proteolysis of HuR by heat shock
Kotb Abdelmohsen,Subramanya Srikantan,Xiaoling Yang,Ashish Lal,Hyeon Ho Kim,Yuki Kuwano,Stefanie Galbán,Kevin G. Becker,Davida Kamara,Rafael de Cabo,Myriam Gorospe +10 more
TL;DR: It is reported that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs and that HuR reduction enhances cell survival following HS.
Journal ArticleDOI
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies
Eun Kyung Lee,Hyeon Ho Kim,Yuki Kuwano,Kotb Abdelmohsen,Subramanya Srikantan,Sarah S. Subaran,Marc Gleichmann,Mohammed Mughal,Jennifer L. Martindale,Xiaoling Yang,Paul F. Worley,Mark P. Mattson,Myriam Gorospe +12 more
TL;DR: Evidence is presented that the RNA-binding proteins (RBPs) heterogeneous nuclear ribonucleoprotein (hnRNP) C and fragile X mental retardation protein (FMRP) associate with the same APP mRNA coding region element, and they influence APP translation competitively and in opposite directions.