K
Krishna P. Kota
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 43
Citations - 1341
Krishna P. Kota is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Virus & Ebola virus. The author has an hindex of 20, co-authored 42 publications receiving 1172 citations. Previous affiliations of Krishna P. Kota include United States Department of the Army & PerkinElmer.
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Journal ArticleDOI
Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin
Sheli R. Radoshitzky,Lian Dong,Xiaoli Chi,Jeremiah C. Clester,Cary Retterer,Kevin B. Spurgers,Jens H. Kuhn,Sarah J. Sandwick,Gordon Ruthel,Krishna P. Kota,Dutch Boltz,Travis K. Warren,Philip J. Kranzusch,Sean P. J. Whelan,Sina Bavari +14 more
TL;DR: The results demonstrate that BST-2 might be a broad antiviral factor with the ability to restrict release of a wide variety of human pathogens, however, at least filoviruses, RVFV, and CPXV are immune to its inhibitory effect.
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IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus
Rajini Mudhasani,Julie P. Tran,Cary Retterer,Sheli R. Radoshitzky,Krishna P. Kota,Louis A. Altamura,Jeffrey M. Smith,Beverly Z. Packard,Jens H. Kuhn,Julie Costantino,Aura R. Garrison,Connie S. Schmaljohn,I-Chueh Huang,Michael Farzan,Sina Bavari +14 more
TL;DR: It is shown that interferon-induced transmembrane protein 1, IFITM-2, and IFITm-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family, including Rift Valley fever virus (RVFV), La Crosse virus, Andes virus, and Hantaan virus, all of which can cause severe disease in humans and animals.
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A Multicomponent Animal Virus Isolated from Mosquitoes
Jason T. Ladner,Michael R. Wiley,Brett Beitzel,Albert J. Auguste,Alan P. Dupuis,Michael E. Lindquist,Samuel D. Sibley,Krishna P. Kota,David P Fetterer,Gillian Eastwood,David Kimmel,Karla Prieto,Hilda Guzman,Matthew T. Aliota,Daniel Reyes,Ernst E. Brueggemann,Lena St. John,David Hyeroba,Michael Lauck,Thomas C. Friedrich,David H. O’Connor,Marie C. Gestole,Lisa H. Cazares,Vsevolod L. Popov,Fanny Castro-Llanos,Tadeusz J. Kochel,Tara Kenny,Bailey White,Michael D. Ward,Jose R. Loaiza,Tony L. Goldberg,Tony L. Goldberg,Scott C. Weaver,Laura D. Kramer,Laura D. Kramer,Robert B. Tesh,Gustavo Palacios +36 more
TL;DR: This study characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Culex virus (GCXV), which belongs to a diverse clade of segmented viruses (Jingmenvirus) related to the prototypically unsegmented Flaviviridae.
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Identification of an antioxidant small-molecule with broad-spectrum antiviral activity
Rekha G. Panchal,St. Patrick Reid,Julie P. Tran,Alison A. Bergeron,Jay Wells,Krishna P. Kota,Javad Aman,Sina Bavari +7 more
TL;DR: Small molecule chemical screening for Ebola virus inhibitors resulted in identification of a compound NSC 62914, which was found to exhibit anti-filovirus activity in cell-based assays and in vivo protected mice following challenge with Ebola or Marburg viruses.
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Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen
Kevin B. Spurgers,Tim Alefantis,Brian D. Peyser,Gordon Ruthel,Alison A. Bergeron,Julie Costantino,Sven Enterlein,Sven Enterlein,Krishna P. Kota,R. C. Dutch Boltz,M. Javad Aman,M. Javad Aman,Vito G. DelVecchio,Sina Bavari +13 more
TL;DR: Host proteins involved in cell adhesion, cytoskeleton, cell signaling, intracellular trafficking, membrane organization, and chaperones were identified and potentially identifies host factors that can be targeted for antiviral drug development.