K
Krista L. Lanctôt
Researcher at Sunnybrook Research Institute
Publications - 433
Citations - 22141
Krista L. Lanctôt is an academic researcher from Sunnybrook Research Institute. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 65, co-authored 376 publications receiving 18155 citations. Previous affiliations of Krista L. Lanctôt include Sunnybrook Health Sciences Centre & University of Toronto.
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Journal ArticleDOI
A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
Journal ArticleDOI
Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
TL;DR: Improvements in sleep with sedative use are statistically significant, but the magnitude of effect is small, and the increased risk of adverse events is statistically significant and potentially clinically relevant in older people at risk of falls and cognitive impairment.
Journal ArticleDOI
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
TL;DR: The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.
Journal ArticleDOI
Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies.
Cristiano A. Köhler,Thiago H. Freitas,Michael Maes,N. Q. De Andrade,Celina S. Liu,Brisa Simoes Fernandes,Brisa Simoes Fernandes,Brendon Stubbs,Brendon Stubbs,Marco Solmi,Nicola Veronese,Nathan Herrmann,Charles L. Raison,Brian J. Miller,Krista L. Lanctôt,André F. Carvalho +15 more
TL;DR: A systematic review and meta‐analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs) is conducted.
Journal Article
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis.
Krista L. Lanctôt,Nathan Herrmann,Kenneth K. Yau,Lyla R. Khan,Barbara A. Liu,Maysoon M. LouLou,Thomas R. Einarson +6 more
TL;DR: A meta-analysis of randomized, double-blind, placebo-controlled, parallel-group trials of currently marketed ChEIs, used in therapeutic doses for at least 12 weeks, results in a modest but significant therapeutic effect and modestly but significantly higher rates of adverse events and discontinuation of treatment.