K
Kristen L. Eckstrand
Researcher at University of Pittsburgh
Publications - 64
Citations - 6055
Kristen L. Eckstrand is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Transgender & Health care. The author has an hindex of 17, co-authored 47 publications receiving 5332 citations. Previous affiliations of Kristen L. Eckstrand include National Institutes of Health & Association of American Medical Colleges.
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Journal ArticleDOI
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Tom Walsh,Jon McClellan,Shane McCarthy,Anjené M. Addington,Sarah B. Pierce,Greg M. Cooper,Alexander Nord,Mary Kusenda,Mary Kusenda,Dheeraj Malhotra,Abhishek Bhandari,Sunday M. Stray,Caitlin Rippey,Patricia Roccanova,Vlad Makarov,B. Lakshmi,Robert L. Findling,Linmarie Sikich,Linmarie Sikich,Thomas Stromberg,Barry Merriman,Nitin Gogtay,Philip Butler,Kristen L. Eckstrand,Laila Noory,Peter Gochman,Robert Long,Zugen Chen,Sean Davis,Carl Baker,Evan E. Eichler,Paul S. Meltzer,Stanley F. Nelson,Andrew B. Singleton,Ming K. Lee,Judith L. Rapoport,Mary Claire King,Jonathan Sebat +37 more
TL;DR: The results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia, and disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways.
Journal ArticleDOI
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
Philip Shaw,Kristen L. Eckstrand,Wendy Sharp,Jonathan D. Blumenthal,Jason P. Lerch,Dede Greenstein,Liv S. Clasen,Alan C. Evans,Jay N. Giedd,Judith L. Rapoport +9 more
TL;DR: Maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas, and there was a marked delay in ADHD in attainingpeak thickness throughout most of the cerebrum.
Journal ArticleDOI
Neurodevelopmental Trajectories of the Human Cerebral Cortex
Philip Shaw,Noor Jehan Kabani,Jason P. Lerch,Kristen L. Eckstrand,Rhoshel K. Lenroot,Nitin Gogtay,Deanna Greenstein,Liv S. Clasen,Alan C. Evans,Judith L. Rapoport,Jay N. Giedd,Steve P. Wise +11 more
TL;DR: By mapping a key characteristic of these development trajectories (the age of attaining peak cortical thickness), this work documents the dynamic, heterochronous maturation of the cerebral cortex through time lapse sequences (“movies”).
Journal ArticleDOI
Development of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder.
Philip Shaw,Francois Lalonde,Claude Lepage,Cara Rabin,Kristen L. Eckstrand,Wendy Sharp,Deanna Greenstein,Alan C. Evans,Jay N. Giedd,Judith L. Rapoport +9 more
TL;DR: These findings explain the way that the increased dimensions of the right frontal and left occipital cortical regions emerge in adulthood from the reversed pattern of childhood cortical asymmetries.
Journal ArticleDOI
Psychostimulant Treatment and the Developing Cortex in Attention Deficit Hyperactivity Disorder
Philip Shaw,Wendy Sharp,Meaghan Morrison,Kristen L. Eckstrand,Deanna Greenstein,Liv S. Clasen,Alan C. Evans,Judith L. Rapoport +7 more
TL;DR: Findings show no evidence that psychostimulant treatment for attention deficit hyperactivity disorder was associated with slowing of overall growth of the cortical mantle.