K
Kristin Eckel-Mahan
Researcher at University of Texas Health Science Center at Houston
Publications - 67
Citations - 4799
Kristin Eckel-Mahan is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 29, co-authored 53 publications receiving 3796 citations. Previous affiliations of Kristin Eckel-Mahan include University of Colorado Denver & University of Texas at Austin.
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Journal ArticleDOI
Reprogramming of the circadian clock by nutritional challenge.
Kristin Eckel-Mahan,Vishal R. Patel,Sara de Mateo,Ricardo Orozco-Solis,Nicholas Ceglia,Saurabh Sahar,Sherry A. Dilag-Penilla,Kenneth A. Dyar,Pierre Baldi,Paolo Sassone-Corsi +9 more
TL;DR: It is demonstrated that it is specifically the nutritional challenge, and not the development of obesity, that causes the reprogramming of the clock and that the effects of the diet on the clock are reversible.
Journal ArticleDOI
Metabolism and the circadian clock converge.
TL;DR: It is becoming more apparent is that from metabolites to transcription factors, the circadian clock interfaces with metabolism in numerous ways that are essential for maintaining metabolic homeostasis.
Journal ArticleDOI
Coordination of the transcriptome and metabolome by the circadian clock
Kristin Eckel-Mahan,Vishal R. Patel,Robert P. Mohney,Katie S. Vignola,Pierre Baldi,Paolo Sassone-Corsi +5 more
TL;DR: This integrated map illustrates the coherence within the circadian metabolome, transcriptome, and proteome and how these are connected through specific nodes that operate in concert to achieve metabolic homeostasis.
Journal ArticleDOI
Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition
Mark S. Sharpley,Mark S. Sharpley,Christine Marciniak,Kristin Eckel-Mahan,Meagan J. McManus,Marco Crimi,Katrina G. Waymire,Chun Shi Lin,Chun Shi Lin,Satoru Masubuchi,Nicole Friend,Nicole Friend,Maya Koike,Dimitra Chalkia,Dimitra Chalkia,Grant R. MacGregor,Paolo Sassone-Corsi,Douglas C. Wallace,Douglas C. Wallace +18 more
TL;DR: Maternal inheritance of mtDNA is the rule in most animals, but the reasons for this pattern remain unclear, and admixture of two normal but different mouse mtDNAs can be genetically unstable and can produce adverse physiological effects, factors that may explain the advantage of uniparental inheritance.
Journal ArticleDOI
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.
Kenneth A. Dyar,Stefano Ciciliot,Lauren E. Wright,Rasmus S. Biensø,Guidantonio Malagoli Tagliazucchi,Vishal R. Patel,Mattia Forcato,Marcia Ivonne Peña Paz,Anders Gudiksen,Francesca Solagna,Mattia Albiero,Irene Moretti,Kristin Eckel-Mahan,Pierre Baldi,Paolo Sassone-Corsi,Rosario Rizzuto,Silvio Bicciato,Henriette Pilegaard,Bert Blaauw,Stefano Schiaffino +19 more
TL;DR: The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.