K
Kristina Abel
Researcher at University of North Carolina at Chapel Hill
Publications - 53
Citations - 2906
Kristina Abel is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Simian immunodeficiency virus & Viral replication. The author has an hindex of 30, co-authored 53 publications receiving 2807 citations. Previous affiliations of Kristina Abel include University of California, Davis & California National Primate Research Center.
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Journal ArticleDOI
Propagation and Dissemination of Infection after Vaginal Transmission of Simian Immunodeficiency Virus
Christopher J. Miller,Qingsheng Li,Kristina Abel,Eun Young Kim,Zhong-Min Ma,Stephen W. Wietgrefe,Lisa La Franco-Scheuch,Lara Compton,Lijie Duan,Marta Dykhuizen Shore,Mary Zupancic,Marc Busch,John V. Carlis,Steven Wolinksy,Ashley T. Haase +14 more
TL;DR: It is shown that the mucosal barrier greatly limits the infection of cervicovaginal tissues, and thus the initial founder populations of infected cells are small, and that continuous seeding from an expanding source of production at the portal of entry is likely critical for the later establishment of a productive infection throughout the systemic LTs.
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CD8+ T-Lymphocyte Response to Major Immunodominant Epitopes after Vaginal Exposure to Simian Immunodeficiency Virus: Too Late and Too Little
Matthew R. Reynolds,Eva G. Rakasz,Pamela J. Skinner,Cara White,Kristina Abel,Zhong-Min Ma,Lara Compton,Gnankang Napoé,Nancy A. Wilson,Christopher J. Miller,Ashley T. Haase,David I. Watkins +11 more
TL;DR: The robust response in female reproductive tissues may be an encouraging sign that vaccines that rapidly induce high-frequency CD8+ T-lymphocyte responses might be able to prevent acquisition of HIV-1 infection by the most common route of transmission.
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Temporal and Anatomic Relationship between Virus Replication and Cytokine Gene Expression after Vaginal Simian Immunodeficiency Virus Infection
TL;DR: Results show that the kinetics of cytokine gene expression levels in the acute phase of infection are positively correlated with virus replication in a tissue, and cytokine responses after vaginal simian immunodeficiency virus (SIV) inoculation are earliest and strongest in mucosal tissues of the genital tract and lowest in systemic lymphoid tissues.
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The Toll-Like Receptor 7 (TLR7) Agonist, Imiquimod, and the TLR9 Agonist, CpG ODN, Induce Antiviral Cytokines and Chemokines but Do Not Prevent Vaginal Transmission of Simian Immunodeficiency Virus When Applied Intravaginally to Rhesus Macaques
Yichuan Wang,Kristina Abel,Katherine Lantz,Arthur M. Krieg,Michael B. McChesney,Christopher J. Miller +5 more
TL;DR: It is concluded that induction of mucosal innate immunity including an IFN-α response is not sufficient to prevent sexual transmission of human immunodeficiency virus.
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Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques
Erin L. Kinnally,E. R. Tarara,William A. Mason,Sally P. Mendoza,Kristina Abel,Leslie A. Lyons,John P. Capitanio +6 more
TL;DR: It is concluded that 5‐HTT regulation is linked with specific, presumably stressful early experiences in infant rhesus macaques and predicted behavioral disinhibition, presumably via parallel processes that operate in the brain.