K
Kristina Luthman
Researcher at University of Gothenburg
Publications - 160
Citations - 7858
Kristina Luthman is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Epoxy & Chromone. The author has an hindex of 39, co-authored 158 publications receiving 7344 citations. Previous affiliations of Kristina Luthman include Pompeu Fabra University & University of Eastern Finland.
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Caco-2 monolayers in experimental and theoretical predictions of drug transport
TL;DR: It is concluded that Caco-2 monolayers can be used to identify drugs with potential absorption problems, and possibly also to select drugs with optimal passive absorption characteristics from series of pharmacologically active molecules generated in drug discovery programs.
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Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans
TL;DR: The results indicate that PS Ad can be used to differentiate poorly absorbed drugs at an early stage of the drug discovery process.
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Correlation of Drug Absorption with Molecular Surface Properties
TL;DR: The results indicate that dynamic polar surface area is a promising alternative model for the prediction of oral drug absorption in two common in vitro models of the intestinal wall.
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Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers.
TL;DR: This perspective focuses on two areas that have yielded new useful information during the last 20 years: structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism.
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Absorption Classification of Oral Drugs Based on Molecular Surface Properties
Christel A. S. Bergström,Melissa Strafford,Lucia Lazorova,Alex Avdeef,Kristina Luthman,Per Artursson +5 more
TL;DR: It is concluded that PLS models of easily comprehended molecular surface properties can be used to rapidly provide absorption profiles of druglike molecules early on in drug discovery.