K
Kristy Kuplast
Publications - 1
Citations - 179
Kristy Kuplast is an academic researcher. The author has contributed to research in topics: P-type calcium channel & Voltage-dependent calcium channel. The author has an hindex of 1, co-authored 1 publications receiving 145 citations.
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T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures
Elizabeth Tringham,Kim L. Powell,Stuart M. Cain,Kristy Kuplast,Janette Mezeyova,Manjula Weerapura,Cyrus Eduljee,Xinpo Jiang,Paula L. Smith,Jerrie Lynn Morrison,Nigel C. Jones,Emma L. Braine,Gil S. Rind,Molly Fee-Maki,David Parker,Hassan Pajouhesh,Manjeet Parmar,Terence J. O'Brien,Terrance P. Snutch +18 more
TL;DR: The ability of the T-type Ca2+ channel antagonists to inhibit absence seizures and to reduce the duration and cycle frequency of spike-and-wave discharges suggests that these agents have a unique mechanism of action on pathological thalamocortical oscillatory activity distinct from current drugs used in clinical practice.