K
Krutika Deshpande
Researcher at University of Southern California
Publications - 7
Citations - 53
Krutika Deshpande is an academic researcher from University of Southern California. The author has contributed to research in topics: Brain metastasis & Metastasis. The author has an hindex of 2, co-authored 7 publications receiving 12 citations.
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Journal ArticleDOI
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination
Vahan Martirosian,Krutika Deshpande,Hao Zhou,Keyue Shen,Kyle S. Smith,Paul A. Northcott,Michelle Lin,Vazgen Stepanosyan,Diganta Das,Ján Remšík,Danielle Isakov,Adrienne Boire,Henk M. De Feyter,Kyle Hurth,Shaobo Li,Joseph L. Wiemels,Brooke N. Nakamura,Ling Shao,Camelia A. Danilov,Thomas C. Chen,Josh Neman +20 more
TL;DR: In this paper, the contribution of receptor-independent GABA metabolism to brain tumor pathogenesis was investigated. But the contribution was not elucidated in the case of primary medulloblastoma (MB) tumors.
Journal ArticleDOI
Clinical Perspectives in Brain Metastasis.
TL;DR: Several challenges, like treatment of multiple CNS lesions, superior uptake of chemotherapy into the brain, and trials with multidisciplinary approaches, are now being clinically addressed.
The microenvironment of brain metastases from solid tumors.
TL;DR: In this paper, the authors discuss unique aspects of the TME in the context of brain metastases and pathways through which they may hold the key to the discovery of new and effective therapies for patients with brain metastasis.
Journal ArticleDOI
Isolation of Neural Stem Cells from Whole Brain Tissues of Adult Mice
TL;DR: This work describes a procedure to purify neurospheres from adult mouse whole brain and provides detailed steps on how to propagate, passage, and maintain the adult neuro Spheres, and how to differentiate the pure neuroSpheres into the lineage of interest.
Journal ArticleDOI
Cortisol promotes breast-to-brain metastasis through the blood-cerebrospinal fluid barrier.
Robert A Herrera,Krutika Deshpande,Vahan Martirosian,Behnaz Saatian,Alex Julian,Rachel Eisenbarth,Diganta Das,Mukund Iyer,Josh Neman +8 more
TL;DR: In this article, the authors provided a novel examination on whether cortisol's role in tumor invasiveness eclipses its supporting role in strengthening the blood-brain-barrier (BBB) to protect the brain from microbes and peripheral immune cells.