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Kuikui Li

Bio: Kuikui Li is an academic researcher from Dalian Institute of Chemical Physics. The author has contributed to research in topics: Medicine & Mutant. The author has an hindex of 6, co-authored 14 publications receiving 117 citations.
Topics: Medicine, Mutant, Lyase, Glycosylation, Glucomannan

Papers
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Journal ArticleDOI
TL;DR: The review focuses on antioxidant and anti-inflammatory roles of POS for promoting human health by regulating some potential oxidative and inflammation-activated pathways, such as ATP-activated protein kinase (AMPK), nuclear factor erythroid-2-related factor-2 (Nrf2), and nuclear factor-κB (NF-κBs) pathways.
Abstract: Colon cancer (CC) is the third common neoplasm worldwide, and it is still a big challenge for exploring new effective medicine for treating CC. Natural product promoting human health has become a hot topic and attracted many researchers recently. Pectin, a complex polysaccharide in plant cell wall, mainly consists of four major types of polysaccharides: homogalacturonan, xylogalacturonan, rhamnogalacturonan I and II, all of which can be degraded into various pectin oligosaccharides (POS) and may provide abundant resource for exploring potential anticancer drugs. POS have been regarded as a novel class of potential functional food with multiple health-promoting properties. POS have antibacterial activities against some aggressive and recurrent bacterial infection and exert beneficial immunomodulation for controlling CC risk. However, the molecular functional role of POS in the prevention of CC risk and progression remains doubtful. The review focuses on antioxidant and anti-inflammatory roles of POS for promoting human health by regulating some potential oxidative and inflammation-activated pathways, such as ATP-activated protein kinase (AMPK), nuclear factor erythroid-2-related factor-2 (Nrf2), and nuclear factor-κB (NF-κB) pathways. The activation of these signaling pathways increases the antioxidant and antiinflammatory activities, which will result in the apoptosis of CC cells or in the prevention of CC risk and progression. Thus, POS may inhibit CC development by affecting antioxidant and antiinflammatory signaling pathways AMPK, Nrf2, and NF-κB. However, POS also can activate signal transduction and transcriptional activator 1 and 3 signaling pathway, which will reduce antioxidant and anti-inflammatory properties and promote CC progression. Specific structural and structurally modified POS may be associated with their functions and should be deeply explored in the future. The present review paper lacks the important information for the linkage between the specific structure of POS and its function. To further explore the effects of prebiotic potential of POS and their derivatives on human immunomodulation in the prevention of CC, the specific POS with a certain degree of polymerization or purified polymers are highly demanded to be performed in clinical practice.

65 citations

Journal ArticleDOI
TL;DR: This study characterized a novel LPMO from Myceliophthora thermophila, denoted MtLPMO9L, which belongs to the C1-oxidized L PMO, which has neither an extra helix in the L3 loop nor extra loop region in theL2 loop, which implies that the composition of cellulase cocktails may need reconsideration.

40 citations

Journal ArticleDOI
TL;DR: Results demonstrated that Alg7A has a great potential to be used to produce oligosaccharides from alginate, and contains a highly conserved domain of the Polysaccharide Lyase 7 family, which indicates that it belongs to PL7.

24 citations

Journal ArticleDOI
TL;DR: The present work is the first to use the engineered yeast strain for direct CPW biomass fermentation produced the OGs, paving a new way to utilize the pectin-rich bioresources.

23 citations

Journal ArticleDOI
TL;DR: Upon combination with a homogenising pre-treatment method with curdlan, the degradation efficiency of CcGluE for curdLAN powder was greatly improved 7.1-fold, which laid a good foundation for the utilisation ofCurdlan.

21 citations


Cited by
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Journal ArticleDOI
TL;DR: The sustainable approaches on the re-utilization of food wastes as the industrial substrates for production of valuable bioproducts has meet the goals of circular bioeconomy, results in the diversify applications and increasing market demands for the biopProducts.

128 citations

Journal ArticleDOI
TL;DR: Current advances and innovation in on-site cellulolytic enzymes production using plant biomass, and application of the enzymes in lignocellulose conversion to fermentable sugars for biofuel production are focused on.
Abstract: The potential of lignocellulosic feedstock has been widely studied, mainly for biofuels production, which usually requires an enzymatic step on the process. Cellulolytic enzymes have been studied as input for bioconversion and as a product from lignocellulose fermentation. The integration of these two perspectives may lead to an economically viable approach for second generation biofuels production, which is nowadays difficult due to high cost of commercial cellulase. Conversely, enzyme production by fermentation of lignocellulosic substrates is inexpensive and the hydrolytic activity of enzymes produced on these substrates, which are to be hydrolyzed, may be better than those enzymes produced on other materials, such as cellulose. Many studies have defined the ideal conditions for cellulase production and saccharification processes separately. In contrast, few reports have developed a unique and integrated process, based on the same feedstock. This review is focused on current advances and innovation in on-site cellulolytic enzymes production using plant biomass, and application of the enzymes in lignocellulose conversion to fermentable sugars for biofuel production.

126 citations

Journal ArticleDOI
TL;DR: Pectin is a natural biopolymer derived from various plant sources and its activity is driven by functional groups and its affinity of pectin and chemical interactions of the active sites to chemicals in media determines fate of adjuvant molecules.

78 citations

Journal ArticleDOI
TL;DR: The results suggest that the side chains of pectin not only augment prebiotic effects but also directly regulate IL-6 production from intestinal host cells in a microbiota-independent fashion to attenuate colitis.
Abstract: Dietary fiber, with intake of soluble fibers in particular, has been reported to lower the risk for developing inflammatory bowel diseases (IBD). This is at least partly attributable to the fermentation of dietary fiber by the colonic microbiota to produce short chain fatty acids. Pectin, a widely consumed soluble fiber, is known to exert a protective effect in murine models of IBD, but the underlying mechanism remains elusive. Apart from having a prebiotic effect, it has been suggested that pectin direct influences host cells by modulating the inflammatory response in a manner dependent on its neutral sugar side chains. Here we examined the effect of the side chain content of pectin on the pathogenesis of experimental colitis in mice. Male C57BL/6 mice were fed a pectin-free diet, or a diet supplemented with characteristically high (5% orange pectin) or low (5% citrus pectin) side chain content for 10-14 days, and then administered 2,4,6-trinitrobenzene sulfonic acid or dextran sulfate sodium to induce colitis. We found that the clinical symptoms and tissue damage in the colon were ameliorated in mice that were pre-fed with orange pectin, but not in those pre-fed with citrus pectin. Although the population of CD4+Foxp+ regulatory T cells and CD4+RORγt+ inflammatory T cells in the colon were comparable between citrus and orange pectin-fed mice, colonic interleukin (IL)-1β and IL-6 levels in orange pectin-fed mice were significantly decreased. The fecal concentration of propionic acid in orange pectin-fed mice was slightly but significantly higher than that in control and citrus pectin-fed mice but the cecal concentration of propionic acid after the induction of TNBS colitis was comparable between orange and citrus pectin-fed mice. Furthermore, the protective effect of orange pectin against colitis was observed even in mice treated with antibiotics. IL-6 production from RAW264.7 cells stimulated with the toll-like receptor agonist Pam3CSK4 or lipopolysaccharide was suppressed by pre-treatment with orange pectin in vitro. Taken together, these results suggest that the side chains of pectin not only augment prebiotic effects but also directly regulate IL-6 production from intestinal host cells in a microbiota-independent fashion to attenuate colitis.

75 citations

Journal ArticleDOI
TL;DR: This paper summarized recently discovered Alys, discussed their characteristics, and introduced their structural properties, degradation patterns and biological roles in alginate-degrading organisms.

70 citations