Author
Kumar Ranabir Sur
Other affiliations: Ramakrishna Mission Vivekananda Centenary College
Bio: Kumar Ranabir Sur is an academic researcher from Centenary College of Louisiana. The author has contributed to research in topics: Benzopyran & Aldehyde. The author has an hindex of 5, co-authored 15 publications receiving 102 citations. Previous affiliations of Kumar Ranabir Sur include Ramakrishna Mission Vivekananda Centenary College.
Topics: Benzopyran, Aldehyde, Sodium naphthalenide, Zinc, Acetic acid
Papers
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TL;DR: K-10 Montmorillonite mediated condensation of aldehyde 1 with arylamine 2 affords chroman-2,4-dione 5 which gives tricoumarol 8 by acid hydrolysis, 4-arylamino-3-formylcoumarin 11 and 1-benzopyrano[4,3-b]quinoline 12 on heating with POCl3 as discussed by the authors.
41 citations
TL;DR: Zn/NH4Cl−mediated reactions of aldehyde with nitro compounds have been studied in this paper, showing that N-alkyl/arylamino)-3-formylchromones can produce 9a-d and 11e-h from 4a−d and 4e−h.
Abstract: Zn/NH4Cl–mediated reactions of aldehyde 1 with nitro compounds 2 afford 2-(N-alkyl/arylamino)-3-formylchromones 4, which on heating with 70% H2SO4 produces 9a-d and 11e-h from 4a-d and 4e-h, respec...
20 citations
TL;DR: The reaction of the title aldehyde 1 with acetylacetone 2 gives benzophenone 8 along with the Knoevenagel-type product 5 under acidic conditions as discussed by the authors.
Abstract: Reaction of the title aldehyde 1 with acetylacetone 2 gives benzophenone 8 along with the Knoevenagel-type product 5 under acidic conditions.
14 citations
TL;DR: The title aldehyde as discussed by the authors gives the bischromones 2, 3, 3 and disalicyloylbenzene 5 with sodium naphthalenide; a mixture of 3 and chromanone 22 with zinc in methanol; 3, carbinol 6 and diol 8 with zinc ion in acetic acid; and acetates 7 and 9 with Zn-Ac2O-AcONa.
Abstract: The title aldehyde 1 gives the bischromones 2, 3 and disalicyloylbenzene 5 with sodium naphthalenide; a mixture of 3 and chromanone 22 with zinc in methanol; 3, carbinol 6 and diol 8 with zinc in acetic acid; and acetates 7 and 9 with Zn–Ac2O–AcONa.
7 citations
TL;DR: In this article, 2-Aminochromones were converted into 4-chlorocoumarins 2a-c and 9-1-c. On treatment with ethylenediamine, they produced 2,3,4,5-tetrahydro-7-(2′-hydroxyphenyl)-1,4-diazepin-5-one 3a,b an...
Abstract: 2-Aminochromones 1a–c and 8a–c are converted into 4-chlorocoumarins 2a–c and 9a–c. On treatment with ethylenediamine, 2a–c produce 2,3,4,5-tetrahydro-7-(2′-hydroxyphenyl)-1,4-diazepin-5-one 3a,b an...
5 citations
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TL;DR: A new series of 4-({[2, 4-dioxo-2H-chromen-3 (4H)-ylidene] methyl} amino) sulfonamides have been obtained by the condensation reaction of4-hydroxycoumarin with various sulf onamides in the presence of an excess of ethylorthoformate and were found to be the most active.
Abstract: A new series of 4-({[2, 4-dioxo-2H-chromen-3 (4H)-ylidene] methyl} amino) sulfonamides have been obtained by the condensation reaction of 4-hydroxycoumarin with various sulfonamides (sulfanilamide, sulfaguanidine, p-aminomethyl-sufanilamide, p-aminoethylsufanilamide, sulfathiazole, sulfamethoxazole, sulfamethazine and 4-[(2-amino-4-pyrimidinyl) amino] benzenesulfonamide) in the presence of an excess of ethylorthoformate. These compounds were screened for their in-vitro antibacterial activity against four Gram-negative (E. coli, S. flexneri, P. aeruginosa and S. typhi) and two Gram-positive (B. subtilis and S. aureus) bacterial strains and for in-vitro antifungal activity against T. longifusus, C. albicans, A. flavus, M. canis, F. solani and C. glaberata. Results revealed that a significant antibacterial activity was observed by compounds (4) and (5), (6) and (8) against two Gram-negative, (P. aeruginosa and S. typhi) and two Gram-positive (B. subtilis and S. aureus) species, respectively. Of these (4) was found to be the most active. Similarly, for antifungal activity compounds (3) and (8) showed significant activity against M. canis and, (6) and (8) against F. solani. The brine shrimp bioassay was also carried out to study their in-vitro cytotoxic properties and only two compounds, (4) and (8) possessing LD50 = 2.9072 x 10(-4) and 3.2844 x 10(-4) M, respectively, displayed potent cytotoxic activity against Artemia salina
119 citations
TL;DR: The N-methylanilino group in 2-(Nmethylonilino)-3-formylchromones, obtained in high yield by rearrangement of C(4-oxo-4H[1]-benzopyran-3-yl)-N-phenylnitrones to 2-anilino-3 -formyl-chromones followed by N-methylation, undergoes facile nucleophilic substitution by a variety of nitrogen nucleophiles, thereby paving the way for synthesis of novel 2-substituted
85 citations
TL;DR: The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one and some of their derivatives and their derivatives were carried out and compound 13 was found to be most potent cytotoxic agent.
Abstract: The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 μg/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.
75 citations
TL;DR: An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe dehydrogenation and a new mild PyBroP-mediated coupling with C, N, O, and S nucleophiles.
Abstract: An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe dehydrogenation and a new mild PyBroP-mediated coupling with C, N, O, and S nucleophiles, which provides a readily accessible multifunctionalized pyrimidine template for diversity-oriented synthesis.
74 citations
71 citations