K
Kumi Ishida
Researcher at Osaka Medical College
Publications - 36
Citations - 426
Kumi Ishida is an academic researcher from Osaka Medical College. The author has contributed to research in topics: Ulcerative colitis & Colitis. The author has an hindex of 12, co-authored 36 publications receiving 389 citations.
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Journal ArticleDOI
Role of Chymase-Dependent Matrix Metalloproteinase-9 Activation in Mice with Dextran Sodium Sulfate-Induced Colitis
Kumi Ishida,Shinji Takai,Mitsuyuki Murano,Takashi Nishikawa,Takuya Inoue,Naoko Murano,Nao Inoue,Denan Jin,Eiji Umegaki,Kazuhide Higuchi,Mizuo Miyazaki +10 more
TL;DR: Findings suggest that chymase plays an important role in the development of colitis via MMP-9 activation through activation in mice treated with 5% dextran sodium sulfate solution.
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Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis in the Regeneration/Healing Process from TNBS-Induced Colitis
Yosuke Abe,Mitsuyuki Murano,Naoko Murano,Eijiro Morita,Takuya Inoue,Ken Kawakami,Kumi Ishida,Takanori Kuramoto,Kazuki Kakimoto,Toshihiko Okada,Ken Narabayashi,Eiji Umegaki,Kazuhide Higuchi +12 more
TL;DR: It is suggested that SIMV induces anti-fibrotic activity that is not directly involved in the anti-inflammatory effect from a relatively early stage the healing process of TNBS-induced colitis.
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Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study
Takanori Kuramoto,Eiji Umegaki,Sadaharu Nouda,Ken Narabayashi,Yuichi Kojima,Yukiko Yoda,Kumi Ishida,Ken Kawakami,Yosuke Abe,Toshihisa Takeuchi,Takuya Inoue,Mitsuyuki Murano,Satoshi Tokioka,Kazuhide Higuchi +13 more
TL;DR: Irsogladine protected against NSAID-induced mucosal injuries throughout the gastrointestinal tract, from esophagus to small intestine, significantly better than omeprazole.
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The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice.
Taisuke Sakanaka,Takuya Inoue,Naoki Yorifuji,Munetaka Iguchi,Kaori Fujiwara,Ken Narabayashi,Kazuki Kakimoto,Sadaharu Nouda,Toshihiko Okada,Takanori Kuramoto,Kumi Ishida,Yosuke Abe,Toshihisa Takeuchi,Eiji Umegaki,Yasutada Akiba,Jonathan D. Kaunitz,Kazuhide Higuchi +16 more
TL;DR: It is hypothesized that luminal TGR5 activation may attenuate intestinal injury via GLP‐2 release, which is enhanced by DPPIV inhibition.
Journal ArticleDOI
Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats.
Kazuki Kakimoto,Shinji Takai,Mitsuyuki Murano,Kumi Ishida,Yukiko Yoda,Takuya Inoue,Denan Jin,Eiji Umegaki,Kazuhide Higuchi +8 more
TL;DR: It is suggested that chymase-dependent MMP-9 activation has a significant role in indomethacin-induced small intestinal damage in rats.