K
Kun Yang
Researcher at Johns Hopkins University
Publications - 60
Citations - 6080
Kun Yang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Biology & Genome. The author has an hindex of 21, co-authored 29 publications receiving 5006 citations. Previous affiliations of Kun Yang include Johns Hopkins University School of Medicine & Peking University.
Papers
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Journal ArticleDOI
Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.
Journal ArticleDOI
Total Synthesis of a Functional Designer Eukaryotic Chromosome
Narayana Annaluru,Héloïse Muller,Leslie A. Mitchell,Sivaprakash Ramalingam,Giovanni Stracquadanio,Sarah M. Richardson,Jessica S. Dymond,Zheng Kuang,Lisa Z. Scheifele,Eric M. Cooper,Yizhi Cai,Karen I. Zeller,Neta Agmon,Jeffrey S. Han,Michalis Hadjithomas,Jennifer Tullman,Katrina Caravelli,Kimberly M. Cirelli,Zheyuan Guo,Viktoriya London,Apurva Yeluru,Sindurathy Murugan,Karthikeyan Kandavelou,Nicolas Agier,Nicolas Agier,Gilles Fischer,Gilles Fischer,Kun Yang,J. Andrew Martin,Murat Bilgel,Pavlo Bohutski,Kristin M. Boulier,Brian J. Capaldo,Joy Chang,Kristie Charoen,Woo Jin Choi,Peter Deng,James E. DiCarlo,Judy Doong,Jessilyn Dunn,Jason I. Feinberg,Christopher Fernandez,Charlotte E. Floria,David Gladowski,Pasha Hadidi,Isabel E. Ishizuka,Javaneh Jabbari,Calvin Y. L. Lau,Pablo A. Lee,Sean Li,Denise Lin,Matthias E. Linder,Jonathan P. Ling,Jaime Liu,Jonathan Liu,Mariya London,Henry Ma,Jessica Mao,Jessica E. McDade,Alexandra McMillan,Aaron M. Moore,Won Chan Oh,Yu Ouyang,Ruchi Patel,Marina Paul,Laura C. Paulsen,Judy Qiu,Alex Rhee,Matthew G. Rubashkin,Ina Y. Soh,Nathaniel E. Sotuyo,Venkatesh Srinivas,Allison Suarez,Andrew D. Wong,Remus S. Wong,Wei Xie,Yijie Xu,Allen T. Yu,Romain Koszul,Romain Koszul,Joel S. Bader,Jef D. Boeke,Srinivasan Chandrasegaran +82 more
TL;DR: SynIII as mentioned in this paper is a designer eukaryotic chromosome based on the S. cerevisiae chromosome III that includes TAG/TAA stop-codon replacements, deletion of subtelomeric regions, introns, transfer RNAs, transposons, and silent mating loci as well as insertion of loxPsym sites.
Journal ArticleDOI
Design of a synthetic yeast genome
Sarah M. Richardson,Sarah M. Richardson,Leslie A. Mitchell,Leslie A. Mitchell,Giovanni Stracquadanio,Giovanni Stracquadanio,Giovanni Stracquadanio,Kun Yang,Kun Yang,Jessica S. Dymond,James E. DiCarlo,Dongwon Lee,Cheng Lai Victor Huang,Srinivasan Chandrasegaran,Yizhi Cai,Yizhi Cai,Jef D. Boeke,Jef D. Boeke,Joel S. Bader,Joel S. Bader +19 more
TL;DR: Complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered is described.
Journal ArticleDOI
"Perfect" designer chromosome v and behavior of a ring derivative
Ze-Xiong Xie,Bing-Zhi Li,Leslie A. Mitchell,Yi Wu,Xin Qi,Zhu Jin,Bin Jia,Xia Wang,Bo Xuan Zeng,Hui Min Liu,Xiao Le Wu,Qi Feng,Wen Zheng Zhang,Wei Liu,Ming Zhu Ding,Xia Li,Guang Rong Zhao,Jian Jun Qiao,Jing Sheng Cheng,Meng Zhao,Zheng Kuang,Xuya Wang,J. Andrew Martin,Giovanni Stracquadanio,Giovanni Stracquadanio,Kun Yang,Xue Bai,Juan Zhao,Meng Long Hu,Qiu Hui Lin,Wen Qian Zhang,Ming Hua Shen,Si Chen,Wan Su,En Xu Wang,Rui Guo,Fang Zhai,Xue Jiao Guo,Hao Xing Du,Jia Qing Zhu,Tian Qing Song,Jun Jun Dai,Fei Fei Li,Guo Zhen Jiang,Shi Lei Han,Shi Yang Liu,Zhi Chao Yu,Xiao Na Yang,Ken Chen,Cheng Hu,Da Shuai Li,Nan Jia,Yue Liu,Lin Ting Wang,Su Wang,Xiao Tong Wei,Mei Qing Fu,Lan Meng Qu,Si Yu Xin,Ting Liu,Kai Ren Tian,Xue Nan Li,Jin Hua Zhang,Li Xiang Song,Jin Gui Liu,Jia Fei Lv,Hang Xu,Ran Tao,Yan Wang,Ting Ting Zhang,Ye Xuan Deng,Yi Ran Wang,Ting Li,Guang Xin Ye,Xiao Ran Xu,Zheng Bao Xia,Wei Zhang,Shi Lan Yang,Yi Lin Liu,Wen Qi Ding,Zhen Ning Liu,Jun Qi Zhu,Ning Zhi Liu,Roy Walker,Yisha Luo,Yun Wang,Yue Shen,Huanming Yang,Yizhi Cai,Ping Sheng Ma,Chun-Ting Zhang,Joel S. Bader,Jef D. Boeke,Ying-Jin Yuan +93 more
TL;DR: The perfect designer-matched synthetic chromosome V provides strategies to edit sequence variants and correct unpredictable events, such as off-target integration of extra copies of synthetic DNA elsewhere in the genome.
Journal ArticleDOI
Bug mapping and fitness testing of chemically synthesized chromosome X
Yi Wu,Bing-Zhi Li,Meng Zhao,Leslie A. Mitchell,Ze-Xiong Xie,Qiu Hui Lin,Xia Wang,Wen Hai Xiao,Ying Wang,Xiao Zhou,Hong Liu,Xia Li,Ming Zhu Ding,Duo Liu,Lu Zhang,Bao Li Liu,Xiao Le Wu,Fei Fei Li,Xiu Tao Dong,Bin Jia,Wen Zheng Zhang,Guo Zhen Jiang,Yue Liu,Xue Bai,Tian Qing Song,Yan Chen,Si Jie Zhou,Rui Ying Zhu,Feng Gao,Zheng Kuang,Xuya Wang,Michael Shen,Kun Yang,Giovanni Stracquadanio,Giovanni Stracquadanio,Sarah M. Richardson,Yicong Lin,Lihui Wang,Roy Walker,Yisha Luo,Ping Sheng Ma,Huanming Yang,Yizhi Cai,Junbiao Dai,Joel S. Bader,Jef D. Boeke,Ying-Jin Yuan +46 more
TL;DR: Synthetic yeast chromosome X was chemically synthesized from scratch, a rigorous, incremental step toward complete synthesis of the whole yeast genome, and an efficient mapping method, PoPM, was developed to identify bugs during genome synthesis, generalizable to any watermarked synthetic chromosome.