Author
Kunihide Mihashi
Other affiliations: Nagasaki University, Kyushu University, University of North Carolina at Chapel Hill
Bio: Kunihide Mihashi is an academic researcher from Fukuoka University. The author has contributed to research in topics: Triterpene & Glycoside. The author has an hindex of 28, co-authored 75 publications receiving 2811 citations. Previous affiliations of Kunihide Mihashi include Nagasaki University & Kyushu University.
Topics: Triterpene, Glycoside, Cyclodextrin, Falcarindiol, Furanocoumarin
Papers published on a yearly basis
Papers
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TL;DR: In this paper, pairs of enantiomers of nine aldoses were separated by gas-liquid chromatography on an OV-17 capillary column as the trimethylsilyl ethers of methyl 2- (polyhydroxyalkyl) -thiazolidine-4 (R) -carboxylates.
Abstract: Pairs of enantiomers of nine aldoses were separated by gas-liquid chromatography on an OV-17 capillary column as the trimethylsilyl ethers of methyl 2- (polyhydroxyalkyl) -thiazolidine-4 (R) -carboxylates, which were obtained by the reaction of aldoses with L-cysteine methyl ester. This method was applied to the determination of the absolute configurations of the component monosaccharides of a Thladiantha saponin.
530 citations
TL;DR: Compounds 1, 3, 12, and 14-16 can serve as new leads for further development of anti-AIDS agents as well as other benzylisoquinoline, aporphine, and bisbenzylisoquoline alkaloids, which were previously isolated from the leaves and embryo of Nelumbo nucifera and evaluated for anti-HIV activity.
375 citations
TL;DR: In this paper, two novel chromane derivatives and the known chromene were isolated from the leaves and twigs of Rhodo-dendron dauricum, and the absolute stereostructures of 1 and 2 were established by spectroscopic examination and X-ray crystallographic analysis.
191 citations
TL;DR: The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth and a new furanocoumarin named japoangelone and four furanOCoumarins ethers of falcarindiol were isolated.
Abstract: The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylhamaudol, and hamaudol). The structures of the new isolates were determined based on spectral evidence. The ED50 of isolates against MK-1, HeLa, and B16F10 cell lines are reported.
148 citations
TL;DR: The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated and anti-cancer activity of the isolated compounds against human gastric adenocarcinoma, uterine carcinoma, and murine melanoma cells was estimated.
Abstract: The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated
134 citations
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TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.
1,728 citations
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.
1,251 citations
TL;DR: Isolation studies of saponins were examined to determine which are the more commonly studied plant families and in which families saponin have been identified.
1,245 citations
TL;DR: Research since the 1986 review has largely upheld the therapeutic claims made in the earlier papers and indeed extended them into other areas and a common theme running though much recent research is the immunomodulatory properties of the gel polysaccharides, especially the acetylated mannans from Aloe vera, which are now a proprietary substance covered by many patents.
815 citations
723 citations