K
Kunisuke Himeno
Researcher at Kyushu University
Publications - 151
Citations - 4731
Kunisuke Himeno is an academic researcher from Kyushu University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 35, co-authored 151 publications receiving 4592 citations. Previous affiliations of Kunisuke Himeno include University of Tokushima & Kurume University.
Papers
More filters
Journal ArticleDOI
Escape of malaria parasites from host immunity requires CD4(+)CD25(+) regulatory T cells
Hajime Hisaeda,Yoichi Maekawa,Daiji Iwakawa,Hiroko Okada,Kunisuke Himeno,Kenji Kishihara,Shin-ichi Tsukumo,Koji Yasutomo +7 more
TL;DR: This paper showed that depletion of CD4+CD25+ regulatory T cells (T(reg)) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens.
Journal ArticleDOI
SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Yoh Ichi Seki,Hiromasa Inoue,Naoko Nagata,Katsuhiko Hayashi,Satoru Fukuyama,Koichiro Matsumoto,Okiru Komine,Shinjiro Hamano,Kunisuke Himeno,Kyoko Inagaki-Ohara,Nicholas A. Cacalano,Anne O'Garra,Tadahilo Oshida,Hirohisa Saito,James A. Johnston,Akihiko Yoshimura,Masato Kubo +16 more
TL;DR: It is suggested that SOCS-3 has an important role in regulating the onset and maintenance of TH2-mediated allergic immune disease, and may be a new therapeutic target for the development of antiallergic drugs.
Journal ArticleDOI
WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production
Shinjiro Hamano,Kunisuke Himeno,Yoshiyuki Miyazaki,Yoshiyuki Miyazaki,Kazunari Ishii,Atsushi Yamanaka,Atsushi Yamanaka,Atsunobu Takeda,Manxin Zhang,Hajime Hisaeda,Tak W. Mak,Akihiko Yoshimura,Hiroki Yoshida,Hiroki Yoshida +13 more
TL;DR: During T. cruzi infection, WSX-1 suppresses liver injury by regulating production of proinflammatory cytokines, while controlling parasitemia by suppression of Th2 responses, demonstrating its novel role as an inhibitory regulator of cytokine production.
Journal ArticleDOI
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1
Ichiko Kinjyo,Hiromasa Inoue,Shinjiro Hamano,Satoru Fukuyama,Takeru Yoshimura,Keiko Koga,Hiromi Takaki,Kunisuke Himeno,Giichi Takaesu,Takashi Kobayashi,Akihiko Yoshimura +10 more
TL;DR: It is proposed that SOCS3 regulates the production of the immunoregulatory cytokines TGF-β1 and IL-10 through modulating STAT3 activation.
Journal ArticleDOI
Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response.
Teruki Dainichi,Yoichi Maekawa,Kazunari Ishii,Tianqian Zhang,B Nashed,Tohru Sakai,Miwa Takashima,Kunisuke Himeno +7 more
TL;DR: N. brasiliensis appears to skillfully evade host immune systems by secreting nippocystatin, which modulates antigen processing in antigen-presenting cells of hosts.