K
Kuo-I Lin
Researcher at Academia Sinica
Publications - 74
Citations - 5609
Kuo-I Lin is an academic researcher from Academia Sinica. The author has contributed to research in topics: Plasma cell differentiation & Cellular differentiation. The author has an hindex of 26, co-authored 73 publications receiving 4990 citations. Previous affiliations of Kuo-I Lin include National Yang-Ming University & National Chiao Tung University.
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Journal ArticleDOI
Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
Arthur L. Shaffer,Kuo-I Lin,Tracy C. Kuo,Xin Yu,Elaine M. Hurt,Andreas Rosenwald,Jena M. Giltnane,Liming Yang,Hong Zhao,Kathryn Calame,Louis M. Staudt +10 more
TL;DR: These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.
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Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells
Miriam Shapiro-Shelef,Kuo-I Lin,Louise J. McHeyzer-Williams,Jerry Liao,Michael G. McHeyzer-Williams,Kathryn Calame +5 more
TL;DR: Mice created with a B cell-specific deletion of prdm1, the gene encoding Blimp-1, show that in response to either TD or TI antigen, serum Ig, short-lived Plasma cells, post-GC plasma cells, and plasma cells in a memory response are virtually absent, demonstrating that Blimp-1 is required for plasmacytic differentiation and Ig secretion.
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Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells
TL;DR: It is shown that repression of Pax-5 is required for Blimp-1 to drive differentiation of splenocytes to immunoglobulin M-secreting cells and plays a critical role in the Blimm-1-dependent program of plasmacytic differentiation.
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Regulatory Mechanisms that Determine the Development and Function of Plasma Cells
TL;DR: The plasmacytic development of germinal center B cells is irreversible by repressing BCL-6 and PAX5 as mentioned in this paper, which are required for germinally center B-1 and marginal zone B cells, respectively.
Journal ArticleDOI
Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo
TL;DR: The expression pattern of Blimp-1 in vivo in primary and secondary lymphoid organs of humans and immunized mice supports a model in which B cell fate decisions occur within the germinal center and Blim-1 expression is critical for commitment to a plasma cell, rather than a memory cell, fate.