Kurt D. Shanebeck

TL;DR: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated, indicating that IL-15 uses components of the IL-2 receptor.

TL;DR: It is concluded that BSF-1 is both a growth factor and a differentiation factor that stimulated the proliferation of several IL-2- and IL-3-dependent cell lines and suggested additional biologic properties of B SF-1 on lineages besides B lymphocytes.

TL;DR: It is shown that recombinant membrane‐bound murine CD40L induces B cells to express costimulatory function for the proliferation of CD4+ Tcells and suggested that CD40 L‐activated B cells express an additional costimulation activity that is not associated with LPS‐ activated B cells.

TL;DR: It is demonstrated that IL‐10 inhibits splenic antigen‐presenting cell (APC)‐dependent proliferation of Th1 clones, at least in part, via down‐regulation of APC‐derived IL‐12, and the failure of activated B cells to provide costimulation via IL‐ 12 accounts for their inability to support optimal proliferative responses of Th 1 clones.

TL;DR: A cell-based mammalian expression system capable of site-specific integration of a non-natural amino acid containing an azide moiety provides a means for the generation of ADCs with optimized pharmacokinetic, biological, and biophysical properties.