K
Kurt Hamacher
Researcher at Forschungszentrum Jülich
Publications - 80
Citations - 5500
Kurt Hamacher is an academic researcher from Forschungszentrum Jülich. The author has contributed to research in topics: Positron emission tomography & Nucleophilic substitution. The author has an hindex of 32, co-authored 80 publications receiving 5293 citations. Previous affiliations of Kurt Hamacher include Massachusetts Institute of Technology.
Papers
More filters
Journal Article
Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution
TL;DR: An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.
Journal ArticleDOI
O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas
Dirk Pauleit,Frank W. Floeth,Kurt Hamacher,Markus J. Riemenschneider,Guido Reifenberger,Hans-Wilhelm Müller,Karl Zilles,Heinz H. Coenen,Karl-Josef Langen +8 more
TL;DR: In this article, the authors investigated whether the diagnostic accuracy of MRI could be improved by the additional use of PET with the amino acid O-(2-[18F]fluoroethyl)-l-tyrosine (FET).
Journal ArticleDOI
O-(2-[18F]fluoroethyl)-l-tyrosine: uptake mechanisms and clinical applications
Karl-Josef Langen,Kurt Hamacher,Matthias Weckesser,Frank W. Floeth,Gabriele Stoffels,Dagmar Bauer,Heinz H. Coenen,Dirk Pauleit +7 more
TL;DR: The tracer exhibits high in vivo stability, low uptake in inflammatory tissue and suitable uptake kinetics for clinical imaging, which indicates that it may become a new standard tracer for PET.
Journal ArticleDOI
Efficient routine production of the 18F-labelled amino acid O-(2-[18F]fluoroethyl)-l-tyrosine
Kurt Hamacher,Heinz H. Coenen +1 more
TL;DR: A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is described, which allows the distribution of the radiotracer to other laboratories according to the satellite concept.
Journal ArticleDOI
A comparative study of N.C.A. fluorine-18 labeling of proteins via acylation and photochemical conjugation.
TL;DR: Owing to competing O-acylation of Tyr residues, [18F]fluoropropionylated HSA was partially unstable under slightly basic conditions, and 18F]SFB seems to be the most suitable 18F-labeling agent for proteins, particularly for the labeling of antibodies.