K
Kurt Højlund
Researcher at Odense University Hospital
Publications - 203
Citations - 11842
Kurt Højlund is an academic researcher from Odense University Hospital. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 52, co-authored 165 publications receiving 10015 citations. Previous affiliations of Kurt Højlund include University of Southern Denmark & Aarhus University Hospital.
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Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
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Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
Martin Mogensen,Kent Sahlin,Maria Fernström,Dorte Glintborg,Birgitte F. Vind,Henning Beck-Nielsen,Kurt Højlund +6 more
TL;DR: Evidence is provided for a functional impairment in mitochondrial respiration and increased amount of type 2X fibers in muscle oftype 2 diabetic patients that may contribute to the development of type 1 diabetes in humans with obesity.
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Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population.
Amalia Gastaldelli,Michaela Kozakova,Kurt Højlund,Allan Flyvbjerg,Angela Favuzzi,Asimina Mitrakou,Beverley Balkau +6 more
TL;DR: In middle‐age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI and the correlations hold also in multivariate analysis after adjusting for age, gender, and recruiting center.
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Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.
Francis M. Finucane,Jian'an Luan,Nicholas J. Wareham,Stephen J. Sharp,Stephen O'Rahilly,B. Balkau,A. Flyvbjerg,Marjorie M. Walker,Kurt Højlund,John J. Nolan,David B. Savage +10 more
TL;DR: The leptin:adiponectin ratio is a useful measure of insulin resistance in non-diabetic white adults and highlights the central role of adipocyte dysfunction in the pathogenesis of insulin Resistance.
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Proteome Analysis Reveals Phosphorylation of ATP Synthase β-Subunit in Human Skeletal Muscle and Proteins with Potential Roles in Type 2 Diabetes
Kurt Højlund,Krzysztof Wrzesinski,Peter Mose Larsen,Stephen J. Fey,Peter Roepstorff,Aase Handberg,Flemming Dela,Jørgen Vinten,James G. McCormack,Christine Reynet,Henning Beck-Nielsen +10 more
TL;DR: It is demonstrated that the catalytic β-subunit of ATP synthase is phosphorylated in vivo and that the levels of a down-regulated ATP synthases β- subunit phosphoisoform in diabetic muscle correlated inversely with fasting plasma glucose levels, suggesting a role for phosphorylation of ATP synthesisation in the regulation of ATP synthesis.