Kurt I. Anderson

TL;DR: It is shown, in a humanized genetically-modified mouse model of pancreatic ductal adenocarcinoma (PDAC), that autophagy’s role in tumour development is intrinsically connected to the status of the tumour suppressor p53, and treatment with hydroxychloroquine significantly accelerates tumour formation in mice containing oncogenic Kras but lacking p53.

TL;DR: Tumor number, growth, and progression were increased by ROCK activation, while ROCK blockade was inhibitory, implicating actomyosin-mediated cellular tension and consequent collagen deposition as significant tumor promoters.

TL;DR: It is proposed that these proteins polarize trafficking of Cadherin-containing exocyst vesicles during junction remodeling, which may be a common mechanism for the action of planar cell polarity proteins in diverse systems.

TL;DR: Data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix.

TL;DR: It is found that RAC1 is required for expansion of the LGR5 intestinal stem cell (ISC) signature, progenitor hyperproliferation, and transformation, and Mechanistically, Rac1-driven ROS and NF-κB signaling mediate these processes.