Kurt Lang

TL;DR: The results indicate that this enzyme is probably identical to cyclophilin, a recently discovered mammalian protein which binds tightly to cyclosporin A (CsA), which is thought to be linked to the immunosuppressive action of CsA.

TL;DR: The enzyme peptidyl-prolyl cis-trans isomerase (PPIase) was discovered and purified from pig kidney and it is shown that it also catalyses slow steps in the refolding of a number of proteins of which fast- and slow-folding species have been observed and where it was suggested that proline isomerization was involved in slow refolding.

TL;DR: IGBP-5 may in part stimulate bone cell proliferation by an IGF-independent mechanism involving IGF BP-5-specific cell surface binding sites independent of IGF receptors, according to studies on the mechanism by which IGFBP- 5 increased the binding of I-IGF tracer to bone cells.

TL;DR: It is shown that IGFBP‐5 inhibits the binding of IGFs to the IGF‐I receptor, resulting in reduction of receptor stimulation and autophosphorylation, and that the smaller N‐terminal fragments were less efficient inhibitors of the IGF-I receptor binding of insulin‐like growth factors.

TL;DR: It is reported here that pro-IL-16 is most likely synthesized as a 67-kDa protein and is encoded from a major 2.6-kb transcript, underlining the potential of IL-16 as an immune regulatory molecule.