K
Kyle D. Mansfield
Researcher at East Carolina University
Publications - 32
Citations - 6108
Kyle D. Mansfield is an academic researcher from East Carolina University. The author has contributed to research in topics: Apoptosis & Chondrocyte. The author has an hindex of 22, co-authored 31 publications receiving 5604 citations. Previous affiliations of Kyle D. Mansfield include Columbia University & University of Pennsylvania.
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Journal ArticleDOI
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Mary A. Selak,Sean M. Armour,Elaine D. MacKenzie,Houda Boulahbel,David G. Watson,Kyle D. Mansfield,Yi Pan,M. Celeste Simon,Craig B. Thompson,Eyal Gottlieb +9 more
TL;DR: A mitochondrion-to-cytosol signaling pathway that links mitochondrial dysfunction to oncogenic events is described, suggesting a mechanistic link between SDH mutations and HIF-1alpha induction, providing an explanation for the highly vascular tumors that develop in the absence of VHL mutations.
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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Robert D. Guzy,Beatrice Hoyos,Emmanuel Robin,Hong Chen,Liping Liu,Liping Liu,Kyle D. Mansfield,M. Celeste Simon,M. Celeste Simon,Ulrich Hämmerling,Paul T. Schumacker +10 more
TL;DR: It is demonstrated that mitochondria function as O(2) sensors and signal hypoxic Hif-1 alpha and HIF-2 alpha stabilization by releasing ROS to the cytosol.
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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.
Nickolai A. Barlev,Lin Liu,Nabil H. Chehab,Kyle D. Mansfield,Kimberly G. Harris,Thanos D. Halazonetis,Shelley L. Berger +6 more
TL;DR: Results with acetylation-defective p53 demonstrate that the critical function of acetylations is not to increase the DNA binding affinity of p53 but rather to promote coactivator recruitment and histoneacetylation.
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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
Kyle D. Mansfield,Robert D. Guzy,Yi Pan,Yi Pan,Regina M. Young,Regina M. Young,Timothy P. Cash,Paul T. Schumacker,M. Celeste Simon,M. Celeste Simon +9 more
TL;DR: Using murine embryonic cells lacking cytochrome c, it is shown that mitochondrial reactive oxygen species (mtROS) are essential for proper O(2) sensing and subsequent Hif-1 alpha and HIF-2 alpha stabilization at 1.5% O( 2).
Journal ArticleDOI
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
Yi Pan,Kyle D. Mansfield,Cara C. Bertozzi,Viktoriya Rudenko,Denise A. Chan,Amato J. Giaccia,M. Celeste Simon,M. Celeste Simon +7 more
TL;DR: It is suggested that multiple mitochondrial products, including TCA cycle intermediates and reactive oxygen species, can coordinate PHD activity, HIF stabilization, and cellular responses to O2 depletion.