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Kyoko Hashimoto
Researcher at University of Alberta
Publications - 25
Citations - 6064
Kyoko Hashimoto is an academic researcher from University of Alberta. The author has contributed to research in topics: Pulmonary hypertension & Vasoconstriction. The author has an hindex of 22, co-authored 25 publications receiving 5666 citations. Previous affiliations of Kyoko Hashimoto include University of Toyama.
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Journal ArticleDOI
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
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Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension Comparison With Inhaled Nitric Oxide
Evangelos D. Michelakis,Wayne Tymchak,Dale Lien,Linda Webster,Kyoko Hashimoto,Stephen L. Archer +5 more
TL;DR: A single oral dose of sildenafil is as effective and selective a pulmonary vasodilator as iNO, and may be superior to iNO in that it increases cardiac output and does not increase wedge pressure.
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Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury Evidence That Angiogenesis Participates in Alveolarization
Bernard Thébaud,Faruqa Ladha,Evangelos D. Michelakis,Monika Sawicka,Gavin Thurston,Farah Eaton,Kyoko Hashimoto,Gwyneth Harry,Alois Haromy,Greg Korbutt,Stephen L. Archer +10 more
TL;DR: These findings underscore the importance of the vasculature in what is traditionally thought of as an airway disease and open new therapeutic avenues for lung diseases characterized by irreversible loss of alveoli through the modulation of angiogenic growth factors.
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Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
M. Sean McMurtry,Sébastien Bonnet,Xichen Wu,Jason R.B. Dyck,Alois Haromy,Kyoko Hashimoto,Evangelos D. Michelakis +6 more
TL;DR: It is shown that dichloroacetate (DCA), a metabolic modulator that increases mitochondrial oxidative phosphorylation, prevents and reverses established monocrotaline-induced PAH (MCT-PAH), significantly improving mortality.
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A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
Gopinath Sutendra,Adam Kinnaird,Peter Dromparis,Roxane Paulin,Trevor H. Stenson,Alois Haromy,Kyoko Hashimoto,Nan Zhang,Eric Flaim,Evangelos D. Michelakis +9 more
TL;DR: It was found that knockdown of nuclear PDC in isolated functional nuclei decreased the de novo synthesis of acetyl-CoA and acetylation of core histones, suggesting a translocation from the mitochondria to the nucleus.