Kyoko Komai

TL;DR: It is shown that there is massive accumulation of Treg cells in the mouse brain after ischaemic stroke, and this potentiates neurological recovery during the chronic phase of ischaemia brain injury.

TL;DR: A novel mechanism of TGF-β induction by Clostridia is revealed through a cooperation between TLR2-AP-1 and T GF-β-Smad signaling pathways.

TL;DR: It is found that diabetic db/db mice which lack the leptin receptor signaling can be used as a model of ESRD associated with DN and systemic administration of rapamycin markedly ameliorated pathological changes and renal dysfunctions, indicating that mTOR activation plays a pivotal role in the development of E SRD.

TL;DR: It is demonstrated that common DAMPs, such as high-mobility-group box 1 (HMGB1), peroxiredoxins, and S100A8 and S 100A9, were internalized through the class A scavenger receptors MSR1 and MARCO in vitro, and cellular mechanisms contributing to DAMP clearance in resolution of the sterile inflammation triggered by tissue injury are uncovered.

TL;DR: It is proposed that SOCS1 and PGE2, potentially interacting together, act as an alternative intestinal tolerance mechanism distinct from IL-10 and Tregs, as an essential mediator of immune tolerance in the intestine.