K
Kyosuke Nakamura
Researcher at University of Copenhagen
Publications - 5
Citations - 600
Kyosuke Nakamura is an academic researcher from University of Copenhagen. The author has contributed to research in topics: DNA replication & Chromatin. The author has an hindex of 5, co-authored 5 publications receiving 452 citations.
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Journal ArticleDOI
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Constance Alabert,Jimi-Carlo Bukowski-Wills,Sung Bau Lee,Georg Kustatscher,Kyosuke Nakamura,Flavia de Lima Alves,Patrice Menard,Jakob Mejlvang,Juri Rappsilber,Juri Rappsilber,Anja Groth +10 more
TL;DR: This work uses nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human cells, and identifies FAM111A as a replication factor required for PCNA loading, providing an extensive resource to understand genome and epigenome maintenance.
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H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids
Kyosuke Nakamura,Giulia Saredi,Giulia Saredi,Jordan R. Becker,Benjamin M. Foster,N V Nguyen,N V Nguyen,Tracey E. Beyer,Laura C. Cesa,Peter Faull,Saulius Lukauskas,Thomas M. Frimurer,Chapman,Till Bartke,Anja Groth +14 more
TL;DR: It is shown that DNA repair pathway choice and initiation of homologous recombination is guided by the recruitment of BRCA1 to post-replicative chromatin by BARD1 recognition of histone H4 tails unmethylated on lysine 20, linking DSB repair pathwaychoice directly to sister chromatid availability.
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Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control
Irene Gallina,Camilla Colding,Peter Henriksen,Petra Beli,Kyosuke Nakamura,Judith Offman,David P. Mathiasen,Sonia Silva,Eva Hoffmann,Anja Groth,Chunaram Choudhary,Michael Lisby +11 more
TL;DR: It is proposed that Cmr1/WDR76 plays a role in the recovery from genotoxic stress through regulation of the turnover of sumoylated and phosphorylated proteins.
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
Saskia Hoffmann,Stine Smedegaard,Kyosuke Nakamura,Gulnahar B. Mortuza,Markus Räschle,Alain Ibáñez de Opakua,Yasuyoshi Oka,Yunpeng Feng,Francisco J. Blanco,Matthias Mann,Guillermo Montoya,Anja Groth,Simon Bekker-Jensen,Niels Mailand +13 more
TL;DR: The E3 ubiquitin ligase TRAIP associates with replication forks through direct interaction with PCNA, promoting checkpoint signaling and genome stability after replication stress.
Journal ArticleDOI
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Kyosuke Nakamura,Georg Kustatscher,Constance Alabert,Martina Hödl,Ignasi Forné,Moritz Völker-Albert,Shankha Satpathy,Tracey E. Beyer,Niels Mailand,Chunaram Choudhary,Axel Imhof,Juri Rappsilber,Juri Rappsilber,Anja Groth +13 more
TL;DR: In this article, the authors used nascent chromatin capture (NCC) proteomics to characterize the repair of replication-associated DNA double-strand breaks (DSBs) triggered by topoisomerase 1 (TOP1) inhibitors.