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Kyoung Hoon Kim

Bio: Kyoung Hoon Kim is an academic researcher from Seoul National University. The author has contributed to research in topics: Rumen & Hanwoo. The author has an hindex of 19, co-authored 81 publications receiving 1133 citations. Previous affiliations of Kyoung Hoon Kim include Konkuk University & Rural Development Administration.


Papers
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Journal ArticleDOI
TL;DR: The present work reports a simple, cost-effective, and ecofriendly method for the synthesis of silver nanoparticles (AgNPs) using Chrysanthemum indicum and its antibacterial and cytotoxic effects, which revealed a significant effect against the bacteria Klebsiella pneumonia and Escherichia coli.
Abstract: The present work reports a simple, cost-effective, and ecofriendly method for the synthesis of silver nanoparticles (AgNPs) using Chrysanthemum indicum and its antibacterial and cytotoxic effects. The formation of AgNPs was confirmed by color change, and it was further characterized by ultraviolet-visible spectroscopy (435 nm). The phytochemical screening of C. indicum revealed the presence of flavonoids, terpenoids, and glycosides, suggesting that these compounds act as reducing and stabilizing agents. The crystalline nature of the synthesized particles was confirmed by X-ray diffraction, as they exhibited face-centered cubic symmetry. The size and morphology of the particles were characterized by transmission electron microscopy, which showed spherical shapes and sizes that ranged between 37.71-71.99 nm. Energy-dispersive X-ray spectroscopy documented the presence of silver. The antimicrobial effect of the synthesized AgNPs revealed a significant effect against the bacteria Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. Additionally, cytotoxic assays showed no toxicity of AgNPs toward 3T3 mouse embryo fibroblast cells (25 μg/mL); hence, these particles were safe to use.

182 citations

Proceedings ArticleDOI
05 Jun 2016
TL;DR: This paper presents an efficient DNN design with stochastic computing by removing near-zero weights, applying weight-scaling, and integrating the activation function with the accumulator to allow an easy implementation of early decision termination with a fixed hardware design.
Abstract: This paper presents an efficient DNN design with stochastic computing. Observing that directly adopting stochastic computing to DNN has some challenges including random error fluctuation, range limitation, and overhead in accumulation, we address these problems by removing near-zero weights, applying weight-scaling, and integrating the activation function with the accumulator. The approach allows an easy implementation of early decision termination with a fixed hardware design by exploiting the progressive precision characteristics of stochastic computing, which was not easy with existing approaches. Experimental results show that our approach outperforms the conventional binary logic in terms of gate area, latency, and power consumption.

148 citations

Journal ArticleDOI
TL;DR: Silver nanoparticles synthesized by using aqueous root extracts of Rheum palmatum and characterized by various spectroscopic methods showed significant activity against Staphylococcus aureus and Pseudomonas aeruginosa, and the protein leakage level was high and morphological changes occurred in bacteria treated with AgNPs.
Abstract: In the present study, silver nanoparticles (AgNPs) were synthesized by using aqueous root extracts of Rheum palmatum and characterized by various spectroscopic methods. The nanoparticles were found to be in hexagonal and spherical shapes. The average particle size was found to be 121 ± 2 nm with zeta potential values of -21.6 mv by dynamic light scattering (DLS) method. Gas chromatography-mass spectrometry (GC-MS) analysis of R. palmatum revealed 35 compounds. The synthesized AgNPs showed significant activity against Staphylococcus aureus and Pseudomonas aeruginosa with IC90 values of 15 μg/ml and IC50 values of 7.5 μg/ml, respectively. The protein leakage level was high and morphological changes occurred in bacteria treated with AgNPs.

137 citations

Journal ArticleDOI
TL;DR: It is reported that hARD1 undergoes autoacetylation and that this modification is essential for its functional activation and its ability to stimulate cancer cell proliferation and tumorigenesis.
Abstract: The N-acetyltransferase arrest defective 1 (ARD1) is an important regulator of cell growth and differentiation that has emerged recently as a critical molecule in cancer progression. However, the regulation of the enzymatic and biological activities of human ARD1 (hARD1) in cancer is presently poorly understood. Here, we report that hARD1 undergoes autoacetylation and that this modification is essential for its functional activation. Using liquid chromatography-tandem mass spectrometry and site-directed mutational analyses, we identified K136 residue as an autoacetylation target site. K136R mutation abolished the ability of hARD1 to promote cancer cell growth in vitro and tumor xenograft growth in vivo. Mechanistic investigations revealed that hARD1 autoacetylation stimulated cyclin D1 expression through activation of the transcription factors β-catenin and activator protein-1. Our results show that hARD1 autoacetylation is critical for its activation and its ability to stimulate cancer cell proliferation and tumorigenesis. Cancer Res; 70(11); 4422–32. ©2010 AACR.

63 citations

Proceedings ArticleDOI
10 Mar 2016
TL;DR: This paper proposes a new SNG that significantly reduces area and energy while improving accuracy in progressive precision and Experimental results show that the proposed SNG reduces energy by more than 72% compared to the state-of-the-art designs.
Abstract: Stochastic circuits provide very high efficiency in terms of gate area and power consumption compared with conventional binary logic. However, they require random bit streams generated by stochastic number generators (SNGs), which account for a significant portion of area and energy offsetting their merits. In this paper, we propose a new SNG that significantly reduces area and energy while improving accuracy in progressive precision. Experimental results show that the proposed SNG reduces energy by more than 72% compared to the state-of-the-art designs.

49 citations


Cited by
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1,610 citations

Journal ArticleDOI
TL;DR: The following tables highlight daily diet dry matter and nutrient density requirements for diffferent classes of cattle at various stages of production based on the National Research Council’s Nutrient Requirements of Beef Cattle.

1,123 citations

Journal ArticleDOI
TL;DR: The potential uses of various biological sources for nanoparticle synthesis and the application of those nanoparticles are explored and the recent milestones achieved are highlighted by controlling critical parameters, including the choice of biological source, incubation period, pH, and temperature.

1,049 citations

Journal ArticleDOI
TL;DR: The antibacterial activity of natural components from different sources including plants, animals, bacteria, algae and mushrooms, and their potential use in food systems are reviewed.

822 citations

Journal ArticleDOI
TL;DR: This review aimed to present major routes of synthesis of AgNPs, including physical, chemical, and biological synthesis processes, along with discrete physiochemical characteristics of AgNs, and discuss the underlying intricate molecular mechanisms behind their plasmonic properties on mono/bimetallic structures, potential cellular/microbial cytotoxicity, and optoelectronic property.
Abstract: Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver nanoparticles (AgNPs) have great potential in a broad range of applications as antimicrobial agents, biomedical device coatings, drug-delivery carriers, imaging probes, and diagnostic and optoelectronic platforms, since they have discrete physical and optical properties and biochemical functionality tailored by diverse size- and shape-controlled AgNPs. In this review, we aimed to present major routes of synthesis of AgNPs, including physical, chemical, and biological synthesis processes, along with discrete physiochemical characteristics of AgNPs. We also discuss the underlying intricate molecular mechanisms behind their plasmonic properties on mono/bimetallic structures, potential cellular/microbial cytotoxicity, and optoelectronic property. Lastly, we conclude this review with a summary of current applications of AgNPs in nanoscience and nanomedicine and discuss their future perspectives in these areas.

775 citations