Kyu Lim

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that autophagy contributes to the cytotoxicity of DHA in cancer cells harboring wild-type p53, and compelling evidence for the interplay betweenAutophagy and apoptosis induced by DHA is supported by the findings that Autophagy inhibition suppressed apoptosis and further autophagic induction enhanced apoptosis in response to DHA treatment.

TL;DR: It is reported that ω-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acids (EPA) inhibit HCC growth through simultaneously inhibition of COX-2 and β-catenin.

TL;DR: Results show that, in addition to apoptosis, DHA increased the expression levels of lipidated form LC3B and potently stimulated the autophagic flux, suggesting that DHA induces both autophagy and apoptosis in cancer cells expressing mutant p53.