L
L. A. Hansen
Researcher at University of California, San Diego
Publications - 69
Citations - 18505
L. A. Hansen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Alzheimer's disease & Lewy body. The author has an hindex of 48, co-authored 66 publications receiving 17791 citations.
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Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.
Journal ArticleDOI
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) Report of the consortium on DLB international workshop
Ian G. McKeith,Douglas Galasko,Kenji Kosaka,Elaine K. Perry,Dennis W. Dickson,L. A. Hansen,David P. Salmon,James Lowe,Suzanne S. Mirra,E. J. Byrne,Graham Lennox,Niall Quinn,J.A. Edwardson,Paul G. Ince,Catherine Bergeron,Alistair Burns,Bruce L. Miller,Simon Lovestone,Daniel Collerton,E. N. H. Jansen,Clive Ballard,R. A. I. De Vos,Gordon K. Wilcock,Kurt A. Jellinger,Robert H. Perry +24 more
TL;DR: This work identified progressive disabling mental impairment progressing to dementia as the central feature of DLB, and identified optimal staining methods for each of these and devised a protocol for the evaluation of cortical LB frequency based on a brain sampling procedure consistent with CERAD.
Journal ArticleDOI
The Lewy body variant of Alzheimer's disease A clinical and pathologic entity
L. A. Hansen,David P. Salmon,Douglas Galasko,Eliezer Masliah,Robert Katzman,Richard DeTeresa,Leon J. Thal,Mary Pay,Richard Hofstetter,Melville R. Klauber,Valerie A. Rice,Nelson Butters,M. Alford +12 more
TL;DR: The patients with LBs appeared to constitute a distinct neuropathologic and clinical subset of AD, the Lewy body variant (LBV), and there was an increase in essential tremor, bradykinesia, mild neck rigidity, and slowing of rapid alternating movements in the LBV group.
Journal ArticleDOI
Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease
Eliezer Masliah,Margaret Mallory,M. Alford,Richard DeTeresa,L. A. Hansen,Daniel W. McKeel,John C. Morris +6 more
TL;DR: Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins, indicating that synaptic injury in frontal cortex is an early event in AD.
Journal ArticleDOI
The importance of neuritic plaques and tangles to the development and evolution of AD.
TL;DR: The significant increase in neuritic plaques, but not neurofibrillary tangles, in patients with even mild Alzheimer disease at death compared with normal control subjects suggests that only neuritic Plaques are associated with the earliest symptoms of Alzheimer disease.